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Differences in benzo(a)pyrene metabolite pattern have been shown by rodent liver microsomes (Sprague-Dawley) and rodent embryo cells from Syrian hamsters and NIH Swiss mice. Rodent liver induced by methylcholanthrene shows marked quantitative variation between species. Additional pattern changes were found in mouse and hamster embryo secondary cultures with a reduction of the K-region metabolites and a marked increase in 9-hydroxybenzo(a)-pyrene. These results are indicative of a region-specific attack on the carcinogen by the cell monooxygenases which is distinct from the liver attack of microsomal enzymes on benzo(a)pyrene. These results suggest that activation and detoxification of benzo(a)pyrene may be species and tissue variable, and susceptibility and resistence to malignant transformation may be predicted on induction of a fortuitous combination of intermediate metabolic steps.
J K Selkirk, and
R G Croy, and
F J Wiebel, and
H V Gelboin
January 1979,
Progress in experimental tumor research,
J K Selkirk, and
R G Croy, and
F J Wiebel, and
H V Gelboin
April 1977,
Biochemical pharmacology,
J K Selkirk, and
R G Croy, and
F J Wiebel, and
H V Gelboin
July 2000,
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP,
J K Selkirk, and
R G Croy, and
F J Wiebel, and
H V Gelboin
January 1987,
The International journal of biochemistry,
J K Selkirk, and
R G Croy, and
F J Wiebel, and
H V Gelboin
January 1985,
Carcinogenesis; a comprehensive survey,
J K Selkirk, and
R G Croy, and
F J Wiebel, and
H V Gelboin
November 1989,
Cancer research,
J K Selkirk, and
R G Croy, and
F J Wiebel, and
H V Gelboin
March 1994,
Comparative biochemistry and physiology. Pharmacology, toxicology and endocrinology,
J K Selkirk, and
R G Croy, and
F J Wiebel, and
H V Gelboin
January 1983,
Toxicology,
J K Selkirk, and
R G Croy, and
F J Wiebel, and
H V Gelboin
January 1980,
Annals of the New York Academy of Sciences,
J K Selkirk, and
R G Croy, and
F J Wiebel, and
H V Gelboin
July 2014,
Toxicology letters,
