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A randomized trial of preoperative radiotherapy in operable breast cancer was conducted from 1971 to 1976. The diagnosis was established by fine-needle aspiration biopsy. A dose of 4500 rad over five weeks was given to the chest wall, the breast and the lymph nodes of the axilla, the supraclavicular fossa and the internal mammary chain. Modified radical mastectomy was performed six weeks or more after completed radiotherapy. In control patients the same operation was performed without prior radiotherapy. By random allocation, one control group received no further treatment and postoperative irradiation was given to the other controls. Preoperative radiotherapy reduced the incidence of local and regional recurrence and of distant metastases, and also the mortality, as compared with the surgery only group. Postoperative radiotherapy as given in this trial gave almost equal reduction of local and regional recurrence but did not diminish the frequency of distant metastases or the mortality.
A Wallgren, and
O Arner, and
J Bergström, and
B Blomstedt, and
P O Granberg, and
L Karnström, and
L Räf, and
C Silfverswärd
January 1977,
Bulletin du cancer,
A Wallgren, and
O Arner, and
J Bergström, and
B Blomstedt, and
P O Granberg, and
L Karnström, and
L Räf, and
C Silfverswärd
May 1995,
Cancer,
A Wallgren, and
O Arner, and
J Bergström, and
B Blomstedt, and
P O Granberg, and
L Karnström, and
L Räf, and
C Silfverswärd
January 1966,
Der Radiologe,
A Wallgren, and
O Arner, and
J Bergström, and
B Blomstedt, and
P O Granberg, and
L Karnström, and
L Räf, and
C Silfverswärd
October 1990,
Diseases of the colon and rectum,
A Wallgren, and
O Arner, and
J Bergström, and
B Blomstedt, and
P O Granberg, and
L Karnström, and
L Räf, and
C Silfverswärd
September 1982,
The British journal of surgery,
A Wallgren, and
O Arner, and
J Bergström, and
B Blomstedt, and
P O Granberg, and
L Karnström, and
L Räf, and
C Silfverswärd
June 1993,
Lancet (London, England),
A Wallgren, and
O Arner, and
J Bergström, and
B Blomstedt, and
P O Granberg, and
L Karnström, and
L Räf, and
C Silfverswärd
July 1997,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
A Wallgren, and
O Arner, and
J Bergström, and
B Blomstedt, and
P O Granberg, and
L Karnström, and
L Räf, and
C Silfverswärd
January 1975,
Radiobiologia, radiotherapia,
A Wallgren, and
O Arner, and
J Bergström, and
B Blomstedt, and
P O Granberg, and
L Karnström, and
L Räf, and
C Silfverswärd
January 2000,
Cancer treatment and research,
A Wallgren, and
O Arner, and
J Bergström, and
B Blomstedt, and
P O Granberg, and
L Karnström, and
L Räf, and
C Silfverswärd
April 2010,
The British journal of surgery,
