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Various techniques have been used to assess the flow properties of blood and blood cells in a range of clinical situations. Filtration through microfilters offers a single technique for measuring the flow properties of all cellular components of blood in one experiment but depends on an assumed ability to recognize cells that make up <10% of leucocytes. The remaining leucocytes, labelled fast leucocytes, were previously presumed to be lymphocytes and granulocytes. This study confirmed the identities of these fast leucocytes as those of lymphocytes and granulocytes in undiluted blood. The transit time for lymphocytes (1.2 s) and granulocytes (1.6 s) is close to that recorded for fast leucocytes (1.7 s). The resistance of each type of blood cell to flow through 5 microm filters was defined in this study as the product of the concentration of that cell in blood and its transit time through a pore in the filter. The total resistance to flow of healthy blood through the filter is 4.46 x 10(7) s/ml and is attributed to plasma (2.7%), red cells (25.9%), fast leucocytes (25.3%) and slow leucocytes (46.1%). In a cohort of 21 men with peripheral arterial disease the total resistance was increased to 7.82 x 10(7) s/ml and attributed to plasma (1.5%), red cells (14.5%), fast leucocytes (21.0%) and slow leucocytes (63.00%). This analysis therefore provides a single test for assessing the flow properties of all the cellular components of blood and plasma.
J G Jones, and
R A Adams, and
A M Cook, and
S A Evans
November 1980,
Southern medical journal,
J G Jones, and
R A Adams, and
A M Cook, and
S A Evans
February 1977,
Der Anaesthesist,
J G Jones, and
R A Adams, and
A M Cook, and
S A Evans
September 2001,
Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi,
J G Jones, and
R A Adams, and
A M Cook, and
S A Evans
January 1977,
Der Anaesthesist,
J G Jones, and
R A Adams, and
A M Cook, and
S A Evans
January 1983,
Bulletins et memoires de la Societe francaise d'ophtalmologie,
J G Jones, and
R A Adams, and
A M Cook, and
S A Evans
March 1995,
Technology and health care : official journal of the European Society for Engineering and Medicine,
J G Jones, and
R A Adams, and
A M Cook, and
S A Evans
December 1990,
Journal of in vitro fertilization and embryo transfer : IVF,
J G Jones, and
R A Adams, and
A M Cook, and
S A Evans
January 1972,
Canadian Anaesthetists' Society journal,
J G Jones, and
R A Adams, and
A M Cook, and
S A Evans
June 1978,
Thorax,
J G Jones, and
R A Adams, and
A M Cook, and
S A Evans
January 1980,
Annales de l'anesthesiologie francaise,
