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Gamma-hydroxybutyrate administered in anesthetic doses produces a time dependent increase in the levels of rat barin acetylcholine. A maximal increase in whole brain and subcortical levels of acetylcholine is observed about 15 min after administration of the lactone form of the drug. A similar GHB-induced increase in acetylcholine is observed in the striatum and a 75% increase in the hippocampus 15 min after administration of the drug. A good temporal correlation was not obtained between the increase in acetylcholine and the depth of anesthesia produced by the drug. Gamma-hydroxybutyrate did not cause a significant change in the striatal or hippocampal levels of choline. Possible mechanisms involved in the production of this increase in acetylcholine are discussed.
V H Sethy, and
R H Roth, and
J R Walters, and
J Marini, and
M H Van Woert
January 1983,
Life sciences,
V H Sethy, and
R H Roth, and
J R Walters, and
J Marini, and
M H Van Woert
January 1981,
Indian journal of physiology and pharmacology,
V H Sethy, and
R H Roth, and
J R Walters, and
J Marini, and
M H Van Woert
June 1971,
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V H Sethy, and
R H Roth, and
J R Walters, and
J Marini, and
M H Van Woert
October 1975,
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V H Sethy, and
R H Roth, and
J R Walters, and
J Marini, and
M H Van Woert
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V H Sethy, and
R H Roth, and
J R Walters, and
J Marini, and
M H Van Woert
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V H Sethy, and
R H Roth, and
J R Walters, and
J Marini, and
M H Van Woert
April 1950,
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V H Sethy, and
R H Roth, and
J R Walters, and
J Marini, and
M H Van Woert
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V H Sethy, and
R H Roth, and
J R Walters, and
J Marini, and
M H Van Woert
April 1980,
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V H Sethy, and
R H Roth, and
J R Walters, and
J Marini, and
M H Van Woert
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Der Anaesthesist,
