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The auditory brainstem response (ABR) was recorded from 20-month-old Long Evans hooded female rats to determine if latency reductions occur from estrogen replacement. The ABR in these post-breeding age rats was also examined for reductions in response latencies as a function of adult age. Tone pip stimuli (8 and 40 kHz) were presented at 21, 51, or 81 s(-1). Aging control and ovariectomized animals showed slower response latencies for waves Ib-VI than young adults for 8 and 40 kHz stimulation at 21 s(-1). Increased stimulus rate resulted in longer latencies for all waves at 20 months. In contrast to hormone treatment effects in young adults, ABR latencies in post-breeding age estrogen-treated animals were not reduced, consistent with a general decrease in CNS responsiveness to estrogen steroids associated with age. The results also suggest that sensorineural modifications in the auditory system which prolong ABR latencies can occur early in the aging process of adult female subjects.
W A Cooper, and
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J R Coleman
January 1990,
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W A Cooper, and
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November 1994,
Hearing research,
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W A Cooper, and
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J R Coleman
January 2013,
Early human development,
W A Cooper, and
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J R Coleman
January 1988,
Electroencephalography and clinical neurophysiology,
W A Cooper, and
K C Ross, and
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Audiology & neuro-otology,
W A Cooper, and
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Hearing research,
W A Cooper, and
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July 1980,
Archives of otolaryngology (Chicago, Ill. : 1960),
W A Cooper, and
K C Ross, and
J R Coleman
June 1991,
Teratology,
W A Cooper, and
K C Ross, and
J R Coleman
June 1994,
Hearing research,
