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Inhibition of prostaglandin (PG) biosynthesis has been proposed as a mechanism of aspirin-induced asthma. In order to verify the existence of a generalized abnormal sensitivity of the PG cyclo-oxygenase in intolerant patients, we have compared the inhibitory effects of aspirin on platelet PGE2 and PGF2alpha spontaneous formation in vitro, in 10 healthy subjects, 10 aspirin-sensitive asthmatics, and 10 nonasthmatic aspirin-sensitive patients. No statistically significant differences were found in the pattern nor in the absolute concentrations of both PGs in the control platelet superfusates. Moreover, the synthesis and release of both PGs were inhibited by aspirin with the same potency in the three groups studied.
C Patrono, and
G Ciabattoni, and
A Venuti, and
F Pugliese, and
D Schiavino, and
G Patriarca
December 1982,
Archivos de farmacologia y toxicologia,
C Patrono, and
G Ciabattoni, and
A Venuti, and
F Pugliese, and
D Schiavino, and
G Patriarca
July 1982,
Prostaglandins, leukotrienes, and medicine,
C Patrono, and
G Ciabattoni, and
A Venuti, and
F Pugliese, and
D Schiavino, and
G Patriarca
October 2011,
British journal of clinical pharmacology,
C Patrono, and
G Ciabattoni, and
A Venuti, and
F Pugliese, and
D Schiavino, and
G Patriarca
August 1982,
Thrombosis research,
C Patrono, and
G Ciabattoni, and
A Venuti, and
F Pugliese, and
D Schiavino, and
G Patriarca
March 1982,
Thrombosis research,
C Patrono, and
G Ciabattoni, and
A Venuti, and
F Pugliese, and
D Schiavino, and
G Patriarca
October 1986,
The Biochemical journal,
C Patrono, and
G Ciabattoni, and
A Venuti, and
F Pugliese, and
D Schiavino, and
G Patriarca
October 1984,
The Biochemical journal,
C Patrono, and
G Ciabattoni, and
A Venuti, and
F Pugliese, and
D Schiavino, and
G Patriarca
October 1978,
Thorax,
C Patrono, and
G Ciabattoni, and
A Venuti, and
F Pugliese, and
D Schiavino, and
G Patriarca
June 1984,
European journal of pharmacology,
C Patrono, and
G Ciabattoni, and
A Venuti, and
F Pugliese, and
D Schiavino, and
G Patriarca
October 1981,
Biochemical pharmacology,
