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Defĩbrase was used for anticoagulation in dogs during extracorporeal perfusion up to 6 hours with a Travenol membrane oxygenator or a Pall filter. The anticoagulation effect was adequate. The already low fibrinogen concentration became unmeasurable, the platelet count decreased, and the fibrin(ogen) degradation products increased during the perfusion. Histological examination showed platelets and white blood cells on the membranes. Perfusion pressure and blood flow were stable during the experiments, and no bleeding, thromboembolism or other adverse side-effects were noted. Defibrase might be an alternative to heparin for anticoagulation during extra-corporeal circulation.
E Berglin, and
Svalander, and
Teger-Nilsson A-C, and
G William-Olsson
February 1999,
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E Berglin, and
Svalander, and
Teger-Nilsson A-C, and
G William-Olsson
July 1976,
Thrombosis research,
E Berglin, and
Svalander, and
Teger-Nilsson A-C, and
G William-Olsson
May 2012,
Perfusion,
E Berglin, and
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Teger-Nilsson A-C, and
G William-Olsson
August 2021,
Hamostaseologie,
E Berglin, and
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G William-Olsson
March 1980,
L'union medicale du Canada,
E Berglin, and
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Teger-Nilsson A-C, and
G William-Olsson
January 1987,
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes,
E Berglin, and
Svalander, and
Teger-Nilsson A-C, and
G William-Olsson
January 1977,
Pflugers Archiv : European journal of physiology,
E Berglin, and
Svalander, and
Teger-Nilsson A-C, and
G William-Olsson
June 2015,
Best practice & research. Clinical anaesthesiology,
E Berglin, and
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Teger-Nilsson A-C, and
G William-Olsson
January 1978,
Transactions - American Society for Artificial Internal Organs,
E Berglin, and
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Teger-Nilsson A-C, and
G William-Olsson
June 1963,
Thorax,
