BIOMAT Database Logo BIOMAT Database Logo

Increase in uncoupling protein-2 mRNA expression by BRL49653 and bromopalmitate in human adipocytes. 1999

N Viguerie-Bascands, and J S Saulnier-Blache, and M Dandine, and M Dauzats, and D Daviaud, and D Langin
INSERM Unit 317, Louis Bugnard Institute, Rangueil Hospital, Paul Sabatier University, Toulouse cedex 4, 31403, France.

Uncoupling protein-2 (UCP2) is a novel mitochondrial protein that may be involved in the control of energy expenditure. We have previously reported an upregulation of adipose tissue UCP2 mRNA expression during fasting in humans. Analysis of changes in metabolic parameters suggested that fatty acids may be associated with the increased UCP2 mRNA level. Culture of human adipose tissue explants was used to study in vitro regulation of adipocyte UCP2 gene expression. A 48-h treatment with BRL49653 and bromopalmitate, two potent activators of PPARgamma, resulted in a dose-dependent increase in UCP2 mRNA levels. The induction by BRL49653 was rapid (from 6 h) and maintained up to 5 days. TNFalpha provoked a 2-fold decrease in UCP2 mRNA levels. Human recombinant leptin did not affect UCP2 mRNA expression. The data support the hypothesis that fatty acids are involved in the control of adipocyte UCP2 mRNA expression in humans.

UI MeSH Term Description Entries
D007473 Ion Channels Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS. Membrane Channels,Ion Channel,Ionic Channel,Ionic Channels,Membrane Channel,Channel, Ion,Channel, Ionic,Channel, Membrane,Channels, Ion,Channels, Ionic,Channels, Membrane
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010168 Palmitates Salts and esters of the 16-carbon saturated monocarboxylic acid--palmitic acid. Hexadecanoates,Palmitate
D011506 Proteins Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein. Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D005260 Female Females
D005786 Gene Expression Regulation Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation. Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000071246 Uncoupling Protein 2 A mitochondrial uncoupling protein that is expressed in many tissues and exhibits the greatest expression in SKELETAL MUSCLE. It regulates mitochondrial ATP production and the generation of REACTIVE OXYGEN SPECIES. Mitochondrial Uncoupling Protein 2,SLC25A8 Protein,Solute Carrier Family 25 Member 8,UCP2 Protein,Uncoupling Protein-2

Related Publications

N Viguerie-Bascands, and J S Saulnier-Blache, and M Dandine, and M Dauzats, and D Daviaud, and D Langin
1alpha,25-dihydroxyvitamin D3 inhibits uncoupling protein 2 expression in human adipocytes.
November 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
N Viguerie-Bascands, and J S Saulnier-Blache, and M Dandine, and M Dauzats, and D Daviaud, and D Langin
Growth factor regulation of uncoupling protein-1 mRNA expression in brown adipocytes.
January 2002, American journal of physiology. Cell physiology,
N Viguerie-Bascands, and J S Saulnier-Blache, and M Dandine, and M Dauzats, and D Daviaud, and D Langin
Depot-related and thiazolidinedione-responsive expression of uncoupling protein 2 (UCP2) in human adipocytes.
May 2000, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity,
N Viguerie-Bascands, and J S Saulnier-Blache, and M Dandine, and M Dauzats, and D Daviaud, and D Langin
Glucose induces and leptin decreases expression of uncoupling protein-2 mRNA in human islets.
February 2002, FEBS letters,
N Viguerie-Bascands, and J S Saulnier-Blache, and M Dandine, and M Dauzats, and D Daviaud, and D Langin
Leptin stimulates uncoupling protein-2 mRNA expression and Krebs cycle activity and inhibits lipid synthesis in isolated rat white adipocytes.
October 2000, European journal of biochemistry,
N Viguerie-Bascands, and J S Saulnier-Blache, and M Dandine, and M Dauzats, and D Daviaud, and D Langin
Regulation of uncoupling protein-2 and uncoupling protein-3 mRNA expression during lipid infusion in human skeletal muscle and subcutaneous adipose tissue.
January 2000, Diabetes,
N Viguerie-Bascands, and J S Saulnier-Blache, and M Dandine, and M Dauzats, and D Daviaud, and D Langin
(-)-Epigallocatechin-3-gallate enhances uncoupling protein 2 gene expression in 3T3-L1 adipocytes.
February 2009, Bioscience, biotechnology, and biochemistry,
N Viguerie-Bascands, and J S Saulnier-Blache, and M Dandine, and M Dauzats, and D Daviaud, and D Langin
Uncoupling protein-2 mRNA expression in mice subjected to intermittent hypoxia.
January 2015, Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia,
N Viguerie-Bascands, and J S Saulnier-Blache, and M Dandine, and M Dauzats, and D Daviaud, and D Langin
Expression of lung uncoupling protein-2 mRNA is modulated developmentally and by caloric intake.
June 2004, Experimental biology and medicine (Maywood, N.J.),
N Viguerie-Bascands, and J S Saulnier-Blache, and M Dandine, and M Dauzats, and D Daviaud, and D Langin
Stimulation of uncoupling protein 1 expression by β-alanine in brown adipocytes.
September 2022, Archives of biochemistry and biophysics,
Copied contents to your clipboard!