Immunization against anaplasmosis and babesiosis: Part I. Evaluation of immunization using minimum infective doses under laboratory conditions. 1976

E F González, and R A Todorovic, and K C Thompson

A method of immunization against anaplasmosis and babesiosis using minimum infective doses was developed under laboratory conditions. Stabilates of Anaplasma marginale stored at -60 degrees C were found infective when diluted 10-fold to 10(-3). Stabilates of Babesia argentina and Babesia bigemina stored under the same conditions were infective when diluted 10-fold to 10(-1). Intact calves inoculated with the above dilutions of stabilates developed moderate parasitemias and recovered from infection without treatment. There was an immune response to vaccination with the formation of specific antibodies to A. marginale, B. bigemina and B. argentina as measured by the complement fixation (CF) test. All calves were found resistant to artificial challenge with lethal doses of the respective parasites.

UI MeSH Term Description Entries
D002417 Cattle Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor. Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D002418 Cattle Diseases Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus. Bovine Diseases,Bovine Disease,Cattle Disease,Disease, Bovine,Disease, Cattle,Diseases, Bovine,Diseases, Cattle
D003168 Complement Fixation Tests Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1. Complement Absorption Test, Conglutinating,Conglutination Reaction,Conglutinating Complement Absorption Test,Complement Fixation Test,Conglutination Reactions,Fixation Test, Complement,Fixation Tests, Complement,Reaction, Conglutination,Reactions, Conglutination,Test, Complement Fixation,Tests, Complement Fixation
D000712 Anaplasmosis A disease usually in cattle caused by parasitization of the red blood cells by bacteria of the genus ANAPLASMA. Anaplasma Infection,Anaplasma phagocytophilum Infection,Human Anaplasmosis,Human Granulocytic Anaplasmosis,Anaplasma Infections,Anaplasma phagocytophilum Infections,Anaplasmoses,Anaplasmoses, Human,Anaplasmoses, Human Granulocytic,Anaplasmosis, Human,Anaplasmosis, Human Granulocytic,Granulocytic Anaplasmoses, Human,Granulocytic Anaplasmosis, Human,Human Anaplasmoses,Human Granulocytic Anaplasmoses,Infection, Anaplasma,Infections, Anaplasma
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000906 Antibodies Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
D001404 Babesiosis A group of tick-borne diseases of mammals including ZOONOSES in humans. They are caused by protozoa of the genus BABESIA, which parasitize erythrocytes, producing hemolysis. In the U.S., the organism's natural host is mice and transmission is by the deer tick IXODES SCAPULARIS. Babesiasis,Piroplasmosis,Babesia Infection,Babesia Parasite Infection,Human Babesiosis,Babesia Infections,Babesia Parasite Infections,Babesiases,Babesioses,Babesioses, Human,Babesiosis, Human,Human Babesioses,Infection, Babesia,Infection, Babesia Parasite,Infections, Babesia,Infections, Babesia Parasite,Piroplasmoses
D012290 Rickettsial Vaccines Vaccines for the prevention of diseases caused by various species of Rickettsia. Vaccines, Rickettsial
D014611 Vaccination Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis. Immunization, Active,Active Immunization,Active Immunizations,Immunizations, Active,Vaccinations
D014612 Vaccines Suspensions of killed or attenuated microorganisms (bacteria, viruses, fungi, protozoa), antigenic proteins, synthetic constructs, or other bio-molecular derivatives, administered for the prevention, amelioration, or treatment of infectious and other diseases. Vaccine

Related Publications

E F González, and R A Todorovic, and K C Thompson
March 1979, Tropenmedizin und Parasitologie,
E F González, and R A Todorovic, and K C Thompson
June 1992, Annals of the New York Academy of Sciences,
E F González, and R A Todorovic, and K C Thompson
June 1998, Annals of the New York Academy of Sciences,
E F González, and R A Todorovic, and K C Thompson
March 1964, Acta virologica,
E F González, and R A Todorovic, and K C Thompson
March 1995, Veterinary parasitology,
E F González, and R A Todorovic, and K C Thompson
January 2000, Annals of the New York Academy of Sciences,
E F González, and R A Todorovic, and K C Thompson
May 1997, Tropical animal health and production,
E F González, and R A Todorovic, and K C Thompson
July 1964, Journal of the American Veterinary Medical Association,
Copied contents to your clipboard!