Biomaterial Database

[Diagnosis and therapy of tumor of Vater's ampulla]. 1999

M Schäffer, and H D Becker

Chirurgische Klinik, Universität Tübingen. mschaeffer@t-online.de

OBJECTIVE Complete removal of tumours of the ampulla (papilla) of Vater is generally recommended, because of the known adenoma-carcinoma sequence yet the uncertainty regarding diagnosis of dignity of such tumours. The aim of this study was tho analyse different treatment concepts on the basis of data from a personal series of cases. METHODS Clinical, laboratory and histological data as well as treatment and course in nine patients (three women, six men; mean age 62 [46-82] years) with ampulla of Vater adenoma, treated at one hospital, were analysed retrospectively. The patients had been followed for 6-36 months. RESULTS All tumours had been removed endoscopically. Partial duodenopancreatectomy had subsequently been performed in two patients because of severe dysplasia. One tumour with moderately severe dysplasia had recurred locally within two months of endoscopic removal and was resected transduodenally. There had been no further recurrences 3 to 36 months later. CONCLUSIONS If there is no evidence of malignity and frequent follow-up can be ensured, endoscopic removal of a tumour of the ampulla of Vater is justified. Otherwise transduodenal excision of the ampulla or partial duodenopancreatectomy should be undertaken.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009364	Neoplasm Recurrence, Local	The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.	Local Neoplasm Recurrence,Local Neoplasm Recurrences,Locoregional Neoplasm Recurrence,Neoplasm Recurrence, Locoregional,Neoplasm Recurrences, Local,Recurrence, Local Neoplasm,Recurrence, Locoregional Neoplasm,Recurrences, Local Neoplasm,Locoregional Neoplasm Recurrences,Neoplasm Recurrences, Locoregional,Recurrences, Locoregional Neoplasm
D003138	Common Bile Duct Neoplasms	Tumor or cancer of the COMMON BILE DUCT including the AMPULLA OF VATER and the SPHINCTER OF ODDI.
D004724	Endoscopy	Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.	Endoscopic Surgical Procedures,Surgical Procedures, Endoscopic,Endoscopic Surgical Procedure,Endoscopy, Surgical,Surgical Endoscopy,Surgical Procedure, Endoscopic,Procedure, Endoscopic Surgical,Procedures, Endoscopic Surgical
D005260	Female		Females
D005500	Follow-Up Studies	Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.	Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000236	Adenoma	A benign epithelial tumor with a glandular organization.	Adenoma, Basal Cell,Adenoma, Follicular,Adenoma, Microcystic,Adenoma, Monomorphic,Adenoma, Papillary,Adenoma, Trabecular,Adenomas,Adenomas, Basal Cell,Adenomas, Follicular,Adenomas, Microcystic,Adenomas, Monomorphic,Adenomas, Papillary,Adenomas, Trabecular,Basal Cell Adenoma,Basal Cell Adenomas,Follicular Adenoma,Follicular Adenomas,Microcystic Adenoma,Microcystic Adenomas,Monomorphic Adenoma,Monomorphic Adenomas,Papillary Adenoma,Papillary Adenomas,Trabecular Adenoma,Trabecular Adenomas
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly