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OBJECTIVE To explore the effect of hypoxia on the proliferation and migration of pulmonary vascular smooth muscle cells (PVSMC), and whether migration of PASMC is involved in the pathogenesis of pulmonary vascular remodeling associated with hypoxia. METHODS In this study, the effect of PDGF, ANP and hypoxia on DNA synthesis and chemotaxis of cultured neonatal calf pulmonary artery smooth muscle cells (PASMC) is investigated by 3H-thymidine incorporation and measurement of cell migration using a 48-well Boyden chamber respectively. RESULTS The results demonstrated that hypoxia could stimulate DNA synthesis and chemotaxis of PASMC induced by PDGF; ANP could inhibit DNA synthesis and chemotaxis of PASMC by a cGMP dependent pathway. CONCLUSIONS It is suggested that PDGF, ANP and hypoxia play important roles in regulating the proliferation and migration of PASMC, which is important in the pathogenesis of hypoxic pulmonary vascular remodeling.
X Feng, and
Y Cai, and
K E Dawes
December 1992,
The American journal of physiology,
X Feng, and
Y Cai, and
K E Dawes
January 1994,
The American journal of physiology,
X Feng, and
Y Cai, and
K E Dawes
December 1996,
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih,
X Feng, and
Y Cai, and
K E Dawes
January 2000,
Pulmonary pharmacology & therapeutics,
X Feng, and
Y Cai, and
K E Dawes
February 2024,
Zhonghua xin xue guan bing za zhi,
X Feng, and
Y Cai, and
K E Dawes
January 2016,
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry,
X Feng, and
Y Cai, and
K E Dawes
October 2009,
Zhonghua xin xue guan bing za zhi,
X Feng, and
Y Cai, and
K E Dawes
November 2002,
Journal of cell science,
X Feng, and
Y Cai, and
K E Dawes
November 2009,
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology,
X Feng, and
Y Cai, and
K E Dawes
March 2005,
Basic research in cardiology,
