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OBJECTIVE To study the antipsoriatic, anti-inflammatory, and analgesic effects of ethanolic extract of red propolis. RESULTS This extract induced the formation of granular layer in the mouse tail test used as a model of psoriasis. Propolis 50 mg.kg-1 i.g. showed anti-inflammatory activity in the cotton-pellet granuloma assay in rats, in croton oil-induced edema in mice at a dose of 25% (2.5 microL), and in the peritoneal capillary permeability test in mice at a dose of 10 mg.kg-1. The extract (25 mg.kg-1 i.g.) showed analgesic effect in the model of acetic acid-induced writhings, whereas 40 mg.kg-1 was effective in the hot plate test in mice. CONCLUSIONS Anti-inflammatory, analgesic, and antipsoriatric properties of Cuban red propolis were evident.
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