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OBJECTIVE To evaluate the clinical efficacy of buprenorphine (Bup) in treatment of acute heroin withdrawal. METHODS Bup was given sublingually daily to 60 cases of heroin addicts in 3 groups: low, medium, and high doses. Withdrawal signs and symptoms of heroin were rated by Clinical Institute Narcotic Assessment. Craving for heroin during detoxification was assessed by Visual Analogue Scale. The side effects of Bup was assessed by Treatment Emergent Symptom Scale. RESULTS The mean daily consumption of Bup in low, medium, and high group was 2.0, 2.9, and 3.6 mg, respectively. Bup not only suppressed objective signs and withdrawal symptoms for heroin withdrawal, but also reduced the duration for heroin detoxification over 7-8 d. CONCLUSIONS Bup is an effective and rapid detoxification agent with fewer side effects for treatment of acute heroin withdrawal.
Z M Liu, and
Z J Cai, and
X P Wang, and
Y Ge, and
C M Li
January 2001,
Journal of psychoactive drugs,
Z M Liu, and
Z J Cai, and
X P Wang, and
Y Ge, and
C M Li
January 2001,
Journal of addictive diseases,
Z M Liu, and
Z J Cai, and
X P Wang, and
Y Ge, and
C M Li
September 2002,
Irish journal of psychological medicine,
Z M Liu, and
Z J Cai, and
X P Wang, and
Y Ge, and
C M Li
January 2000,
The American journal on addictions,
Z M Liu, and
Z J Cai, and
X P Wang, and
Y Ge, and
C M Li
June 2009,
Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence,
Z M Liu, and
Z J Cai, and
X P Wang, and
Y Ge, and
C M Li
March 2007,
Addiction (Abingdon, England),
Z M Liu, and
Z J Cai, and
X P Wang, and
Y Ge, and
C M Li
December 2000,
Current psychiatry reports,
Z M Liu, and
Z J Cai, and
X P Wang, and
Y Ge, and
C M Li
January 2002,
The Israel journal of psychiatry and related sciences,
Z M Liu, and
Z J Cai, and
X P Wang, and
Y Ge, and
C M Li
January 2005,
Journal of opioid management,
Z M Liu, and
Z J Cai, and
X P Wang, and
Y Ge, and
C M Li
October 2002,
Journal of substance abuse treatment,
