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The objective of this study was to determine the pharmacokinetics of trimetrexate and dapsone in AIDS patients with moderate to severe pneumocystis pneumonia. Trimetrexate, leucovorin, and dapsone were administered for 21 +/- 3 days in the following doses: trimetrexate glucuronate, 45 mg/m2; leucovorin, 20 mg/m2; and dapsone, 100 mg daily. The pharmacokinetics of trimetrexate, dapsone, and dapsone's metabolite, monoacetyldapsone, were determined at three separate periods over the course of treatment. Serial blood samples were obtained over 24 hours after dosing and analyzed for trimetrexate, dapsone, and monoacetyldapsone, and pharmacokinetic parameters were determined. The mean parameters obtained for the early, mid-, and late collection periods were the following: trimetrexate: t1/2 = 8.29, 9.15, 10.00 hr; AUC = 16.85, 22.38, 24.49 mg.hr/l; CI = 5.58, 4.14, 3.96 l/hr, respectively. DDS: t1/2 = 14.99, 16.59, 15.13 hr; AUC = 30.60, 35.29, 36.08 mg.hr/l; CI = 3.82, 3.49, 3.01 l/hr, respectively. Monoacetyldapsone: t1/2 = 20.25, 18.66, 16.32 hr; AUC = 24.05, 24.06, 23.86 mg.hr/l, respectively. No statistically significant changes in pharmacokinetics for trimetrexate or dapsone were observed over the 21 +/- 3 day course of treatment. The results suggest that there are no major interactions between trimetrexate and dapsone when administered together in acutely ill patients.
R T Koda, and
M P Dubé, and
W Y Li, and
D J Chatterjee, and
J D Stansell, and
F R Sattler
February 1992,
The Annals of pharmacotherapy,
R T Koda, and
M P Dubé, and
W Y Li, and
D J Chatterjee, and
J D Stansell, and
F R Sattler
October 1993,
Annals of the New York Academy of Sciences,
R T Koda, and
M P Dubé, and
W Y Li, and
D J Chatterjee, and
J D Stansell, and
F R Sattler
April 1988,
Fortschritte der Medizin,
R T Koda, and
M P Dubé, and
W Y Li, and
D J Chatterjee, and
J D Stansell, and
F R Sattler
January 1989,
The Medical letter on drugs and therapeutics,
R T Koda, and
M P Dubé, and
W Y Li, and
D J Chatterjee, and
J D Stansell, and
F R Sattler
April 1988,
Seminars in oncology,
R T Koda, and
M P Dubé, and
W Y Li, and
D J Chatterjee, and
J D Stansell, and
F R Sattler
October 1988,
British journal of clinical pharmacology,
R T Koda, and
M P Dubé, and
W Y Li, and
D J Chatterjee, and
J D Stansell, and
F R Sattler
March 1987,
Nederlands tijdschrift voor geneeskunde,
R T Koda, and
M P Dubé, and
W Y Li, and
D J Chatterjee, and
J D Stansell, and
F R Sattler
November 1990,
AIDS (London, England),
R T Koda, and
M P Dubé, and
W Y Li, and
D J Chatterjee, and
J D Stansell, and
F R Sattler
March 2004,
The American journal of the medical sciences,
R T Koda, and
M P Dubé, and
W Y Li, and
D J Chatterjee, and
J D Stansell, and
F R Sattler
January 1992,
The Annals of pharmacotherapy,
