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A chromosomal abnormality in one of the fetuses of a monozygotic twin pregnancy is a rare phenomenon. In the prenatal unit of our cytogenetics laboratory we have recently come across two such heterokaryotypic twin pregnancies. In both cases ultrasound abnormalities were detected in one fetus of each twin pair. Chromosomal analysis showed that one twin pregnancy was discordant for trisomy 21 and the other for 45,X. Ultrasonographic examination suggested a monochorionic twin pregnancy in each case and DNA studies confirmed that both sets of twins were monozygotic. Both pregnancies were terminated. Biopsies taken from different sites of the placentas showed chromosomal mosaicism in both cases. There was no clear correlation between the karyotype found close to the site of the umbilical cord insertion in the placenta and the karyotype of the fetus. Sampling of amniotic fluid from both sacs is recommended in diamniotic twin pregnancies if one (or both) of the fetuses has ultrasound abnormalities, even if the twins are apparently monochorionic.
A Nieuwint, and
R Van Zalen-Sprock, and
P Hummel, and
G Pals, and
J Van Vugt, and
H Van Der Harten, and
Y Heins, and
K Madan
September 2004,
The Journal of pediatrics,
A Nieuwint, and
R Van Zalen-Sprock, and
P Hummel, and
G Pals, and
J Van Vugt, and
H Van Der Harten, and
Y Heins, and
K Madan
January 1973,
The Practitioner,
A Nieuwint, and
R Van Zalen-Sprock, and
P Hummel, and
G Pals, and
J Van Vugt, and
H Van Der Harten, and
Y Heins, and
K Madan
August 1972,
The Practitioner,
A Nieuwint, and
R Van Zalen-Sprock, and
P Hummel, and
G Pals, and
J Van Vugt, and
H Van Der Harten, and
Y Heins, and
K Madan
January 1983,
Clinical and experimental rheumatology,
A Nieuwint, and
R Van Zalen-Sprock, and
P Hummel, and
G Pals, and
J Van Vugt, and
H Van Der Harten, and
Y Heins, and
K Madan
May 1964,
The Journal of nervous and mental disease,
A Nieuwint, and
R Van Zalen-Sprock, and
P Hummel, and
G Pals, and
J Van Vugt, and
H Van Der Harten, and
Y Heins, and
K Madan
January 1947,
Archiv der Julius Klaus-Stiftung fur Vererbungsforschung, Sozialanthropologie und Rassenhygiene,
A Nieuwint, and
R Van Zalen-Sprock, and
P Hummel, and
G Pals, and
J Van Vugt, and
H Van Der Harten, and
Y Heins, and
K Madan
January 1961,
El Dia medico,
A Nieuwint, and
R Van Zalen-Sprock, and
P Hummel, and
G Pals, and
J Van Vugt, and
H Van Der Harten, and
Y Heins, and
K Madan
March 1990,
Journal of medical genetics,
A Nieuwint, and
R Van Zalen-Sprock, and
P Hummel, and
G Pals, and
J Van Vugt, and
H Van Der Harten, and
Y Heins, and
K Madan
October 1972,
The Practitioner,
A Nieuwint, and
R Van Zalen-Sprock, and
P Hummel, and
G Pals, and
J Van Vugt, and
H Van Der Harten, and
Y Heins, and
K Madan
October 1998,
American journal of medical genetics,
