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We studied the effects of endogenous and synthetic opioids on survival of primary-cultured dorsal root ganglion neurons of 8-day chick embryos. In the basal growth medium containing nerve growth factor (NGF), [Leu5]enkephalin, [Met5]enkephalin or selective mu-agonist, [D-Ala2, N-Me-Phe4, Gly5-ol]enkephalin (DAMGO) produced significant increase of neuronal survival in a naloxone-reversible manner. On the other hand, dynorphin A (1-13), [D-Pen2, L-Pen5] enkephalin (DPLPE) (a delta-agonist) and U-50,488 (a kappa-agonist) showed no such effect. No viable neurons were observed in the absence of NGF in spite of the presence of any opioid peptides. These results suggest that [Leu5]enkephalin and [Met5]enkephalin might increase neuronal survival by stimulating mu-opioid receptors, and that these opioid peptides are working with other growth factors but, in and by themselves, do not promote survival.
M Sakaguchi, and
T Fujimori, and
T Satoh, and
M Satoh, and
M Takeuchi, and
E Matsumura
November 1992,
Brain research. Developmental brain research,
M Sakaguchi, and
T Fujimori, and
T Satoh, and
M Satoh, and
M Takeuchi, and
E Matsumura
September 1967,
Experimental cell research,
M Sakaguchi, and
T Fujimori, and
T Satoh, and
M Satoh, and
M Takeuchi, and
E Matsumura
April 1981,
Journal of neurophysiology,
M Sakaguchi, and
T Fujimori, and
T Satoh, and
M Satoh, and
M Takeuchi, and
E Matsumura
August 2014,
Cold Spring Harbor protocols,
M Sakaguchi, and
T Fujimori, and
T Satoh, and
M Satoh, and
M Takeuchi, and
E Matsumura
July 1994,
Spine,
M Sakaguchi, and
T Fujimori, and
T Satoh, and
M Satoh, and
M Takeuchi, and
E Matsumura
June 2000,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
M Sakaguchi, and
T Fujimori, and
T Satoh, and
M Satoh, and
M Takeuchi, and
E Matsumura
January 1985,
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience,
M Sakaguchi, and
T Fujimori, and
T Satoh, and
M Satoh, and
M Takeuchi, and
E Matsumura
January 2004,
Neuroscience,
M Sakaguchi, and
T Fujimori, and
T Satoh, and
M Satoh, and
M Takeuchi, and
E Matsumura
March 1997,
Brain research,
M Sakaguchi, and
T Fujimori, and
T Satoh, and
M Satoh, and
M Takeuchi, and
E Matsumura
May 2013,
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association,
