1. Changes occuring in the activity of SGOT after uncomplicated gynecological operations conducted for benign diseases are not extensive. They manifest themselves in form of a moderate SGOT activity increase which was not statistically significant in the present sample. 2. In about half the number of patients of women operated per laparotomiam there was a fairly marked increase in the activity of SGOT which reached in fairly frequent instances the upper physiological limit. 3. Even a completely smooth and uncomplicated preoperative and postoperative course may be associated in some patients with a tissue lesion and liver function change reaching a level which causes the SGOT activity to increase. The above finding should be taken into account during postoperative treatment in particular in women in whom a change of this might produce exacerbation of an associated disease (liver disease) or lead to the rise of complications.