BIOMAT Database Logo BIOMAT Database Logo

Inhibition of murine granulopoiesis in vitro by dexamethasone. 1976

D W Golde, and N Bersch, and S G Quan, and M J Cline

The effect of dexamethasone on mouse bone marrow granulocyte-monocyte precursor cells (CFU-C) was studied in vitro. Dexamethasone inhibited colony formation in the presence of maximally stimulating concentrations of colony-stimulating activity. A mean colony reduction of 55% occurred at 10(-9) M dexamethasone and inhibition was observed at concentrations as low as 10(-12)M. The dexamethasone suppression could be abrogated by progesterone. These studies provide evidence that the committed granulocyte-monocyte stem cell has a glucocorticoid receptor mechanism that when activated results in inhibition of cellular proliferation in vitro.

UI MeSH Term Description Entries
D007962 Leukocytes White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES). Blood Cells, White,Blood Corpuscles, White,White Blood Cells,White Blood Corpuscles,Blood Cell, White,Blood Corpuscle, White,Corpuscle, White Blood,Corpuscles, White Blood,Leukocyte,White Blood Cell,White Blood Corpuscle
D008747 Methylcellulose Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative. BFL,Celevac,Cellothyl,Cellulone,Citrucel,Cologel,Dacryolarmes,Methocel,Methyl Cellulose,Muciplasma,Cellulose, Methyl
D011239 Prednisolone A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. Di-Adreson-F,Predate,Predonine,Di Adreson F,DiAdresonF
D011374 Progesterone The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS. Pregnenedione,Progesterone, (13 alpha,17 alpha)-(+-)-Isomer,Progesterone, (17 alpha)-Isomer,Progesterone, (9 beta,10 alpha)-Isomer
D003907 Dexamethasone An anti-inflammatory 9-fluoro-glucocorticoid. Hexadecadrol,Decaject,Decaject-L.A.,Decameth,Decaspray,Dexasone,Dexpak,Hexadrol,Maxidex,Methylfluorprednisolone,Millicorten,Oradexon,Decaject L.A.
D006098 Granulocytes Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS. Granulocyte
D006410 Hematopoiesis The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY). Hematopoiesis, Medullary,Haematopoiesis,Medullary Hematopoiesis
D000362 Agar A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.
D000431 Ethanol A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES. Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

D W Golde, and N Bersch, and S G Quan, and M J Cline
In vitro studies of lactoferrin and murine granulopoiesis.
March 1981, Blood,
D W Golde, and N Bersch, and S G Quan, and M J Cline
In vitro inhibition of granulopoiesis by 4-amino-4'-hydroxylaminodiphenyl sulfone.
July 1980, British journal of haematology,
D W Golde, and N Bersch, and S G Quan, and M J Cline
Inhibition of in vitro granulopoiesis by autologous allogeneic human NK cells.
July 1982, Journal of immunology (Baltimore, Md. : 1950),
D W Golde, and N Bersch, and S G Quan, and M J Cline
Inhibition of granulopoiesis in vivo and in vitro by beta-lactam antibiotics.
July 1985, The Journal of infectious diseases,
D W Golde, and N Bersch, and S G Quan, and M J Cline
Inhibition of normal human granulopoiesis in vitro by non-B non-T lymphocytes.
August 1980, British journal of haematology,
D W Golde, and N Bersch, and S G Quan, and M J Cline
In vivo inhibition of tumour growth by dexamethasone in murine osteosarcomas.
September 2001, European journal of cancer (Oxford, England : 1990),
D W Golde, and N Bersch, and S G Quan, and M J Cline
In vivo stimulation and inhibition of granulopoiesis: the effect of an inflammatory reaction on murine diffusion chamber granulopoiesis.
May 1982, British journal of haematology,
D W Golde, and N Bersch, and S G Quan, and M J Cline
Simulation of murine granulopoiesis.
July 1980, Blut,
D W Golde, and N Bersch, and S G Quan, and M J Cline
Inhibition by dexamethasone of human neutrophil apoptosis in vitro.
April 1995, Natural immunity,
D W Golde, and N Bersch, and S G Quan, and M J Cline
[Granulopoiesis in vitro].
January 1974, Nouvelle revue francaise d'hematologie,
Copied contents to your clipboard!