BIOMAT Database Logo BIOMAT Database Logo

Arginase from human full-term placenta. 1976

R Porta, and C Esposito, and A Martin, and G D Pietra

Arginase was purified about 1800-fold from extracts of human full-term placenta; the enzyme appeared to be homogenous by disc electrophoresis and molecular-sieve chromatography. The mol. wt. determination by gel filtration and sodium dodecyl sulphate/polyacrylamide-gel electrophoresis yielded a value of 70000 for the most pure and the partially purified enzyme. The human placenta arginase is a metalloenzyme with an optimum pH of 9.1. The Km for L-arginine is 27 mM. L-Ornithine and L-lysine show competitive inhibition with Ki values of 6.3 and 14 mM respectively.

UI MeSH Term Description Entries
D008345 Manganese A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
D008970 Molecular Weight The sum of the weight of all the atoms in a molecule. Molecular Weights,Weight, Molecular,Weights, Molecular
D010920 Placenta A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES). Placentoma, Normal,Placentome,Placentas,Placentomes
D002850 Chromatography, Gel Chromatography on non-ionic gels without regard to the mechanism of solute discrimination. Chromatography, Exclusion,Chromatography, Gel Permeation,Chromatography, Molecular Sieve,Gel Filtration,Gel Filtration Chromatography,Chromatography, Size Exclusion,Exclusion Chromatography,Gel Chromatography,Gel Permeation Chromatography,Molecular Sieve Chromatography,Chromatography, Gel Filtration,Exclusion Chromatography, Size,Filtration Chromatography, Gel,Filtration, Gel,Sieve Chromatography, Molecular,Size Exclusion Chromatography
D004789 Enzyme Activation Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme. Activation, Enzyme,Activations, Enzyme,Enzyme Activations
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001119 Arginase A ureahydrolase that catalyzes the hydrolysis of arginine or canavanine to yield L-ornithine (ORNITHINE) and urea. Deficiency of this enzyme causes HYPERARGININEMIA. EC 3.5.3.1. Arginase A1,Arginase A4,Hepatic Proliferation Inhibitor,Liver Immunoregulatory Protein,Liver-Derived Inhibitory Protein,Liver-Derived Lymphocyte Proliferation Inhibiting Protein,Immunoregulatory Protein, Liver,Inhibitor, Hepatic Proliferation,Inhibitory Protein, Liver-Derived,Liver Derived Inhibitory Protein,Liver Derived Lymphocyte Proliferation Inhibiting Protein,Proliferation Inhibitor, Hepatic,Protein, Liver Immunoregulatory,Protein, Liver-Derived Inhibitory

Related Publications

R Porta, and C Esposito, and A Martin, and G D Pietra
Isolation of trophoblast basement membrane from full-term human placenta.
May 1972, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
R Porta, and C Esposito, and A Martin, and G D Pietra
Proteases in the human full-term placenta.
January 1987, Histochemistry,
R Porta, and C Esposito, and A Martin, and G D Pietra
[Isolation of protein kinase C isoforms from human full-term placenta].
January 1991, Annales d'endocrinologie,
R Porta, and C Esposito, and A Martin, and G D Pietra
The ultrastructure of the human full-term placenta.
February 1962, Journal of ultrastructure research,
R Porta, and C Esposito, and A Martin, and G D Pietra
Seasonally variant gene expression in full-term human placenta.
August 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
R Porta, and C Esposito, and A Martin, and G D Pietra
Isolation and characterization of chorionic mesenchymal stromal cells from human full term placenta.
August 2012, Journal of Korean medical science,
R Porta, and C Esposito, and A Martin, and G D Pietra
Effect of anti-HCG sera on purified syncytiotrophoblast from full-term human placenta.
February 1982, American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction,
R Porta, and C Esposito, and A Martin, and G D Pietra
[Fetal blood vessel system of the human full-term placenta].
May 1973, Zeitschrift fur Zellforschung und mikroskopische Anatomie (Vienna, Austria : 1948),
R Porta, and C Esposito, and A Martin, and G D Pietra
Expression of MUC1 mucin in full-term pregnancy human placenta.
January 2008, Advances in medical sciences,
R Porta, and C Esposito, and A Martin, and G D Pietra
[CHORIOANGIOMA IN A FULL TERM PLACENTA].
September 1963, Magyar noorvosok lapja,
Copied contents to your clipboard!