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2-3-Dihydroxybenzoic acid was evaluated as a potentially useful, orally effective iron-chelating drug by performing iron balance studies in patients with beta-thalassaemia major. The administration of this substance at 25 mg/kg/d to five patients for 8 d caused an average increase in iron excretion of 4.5 mg/d. When the drug was administered at 25 mg/kg q.i.d. to eight patients for 21 d, iron excretion increased to 6.5 mg/d. Chelation was highly specific for iron with changes in magnesium and calcium excretion being insignificant. The drug was well tolerated with side effects limited to gastrointestinal complaints which ameliorated when the drug was taken with food. These studies provide a rationale for further evaluation of 2,3-dihydroxybenzoic acid in patients with iron overload.
C M Peterson, and
J H Graziano, and
R W Grady, and
R L Jones, and
H V Vlassara, and
V C Canale, and
D R Miller, and
A Cerami
October 2006,
British journal of haematology,
C M Peterson, and
J H Graziano, and
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H V Vlassara, and
V C Canale, and
D R Miller, and
A Cerami
February 1977,
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C M Peterson, and
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H V Vlassara, and
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A Cerami
December 2009,
Blood reviews,
C M Peterson, and
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H V Vlassara, and
V C Canale, and
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A Cerami
October 1967,
Biochimica et biophysica acta,
C M Peterson, and
J H Graziano, and
R W Grady, and
R L Jones, and
H V Vlassara, and
V C Canale, and
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A Cerami
May 1977,
Monatsschrift fur Kinderheilkunde,
C M Peterson, and
J H Graziano, and
R W Grady, and
R L Jones, and
H V Vlassara, and
V C Canale, and
D R Miller, and
A Cerami
April 2007,
Diabetes research and clinical practice,
C M Peterson, and
J H Graziano, and
R W Grady, and
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H V Vlassara, and
V C Canale, and
D R Miller, and
A Cerami
May 2022,
Vox sanguinis,
C M Peterson, and
J H Graziano, and
R W Grady, and
R L Jones, and
H V Vlassara, and
V C Canale, and
D R Miller, and
A Cerami
December 2000,
The Medical journal of Malaysia,
C M Peterson, and
J H Graziano, and
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H V Vlassara, and
V C Canale, and
D R Miller, and
A Cerami
January 1976,
Birth defects original article series,
C M Peterson, and
J H Graziano, and
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R L Jones, and
H V Vlassara, and
V C Canale, and
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A Cerami
January 1989,
Journal of psychosomatic research,
