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Brasilicardin A, a new terpenoid antibiotic from pathogenic Nocardia brasiliensis: fermentation, isolation and biological activity. 1999
H Komaki, and
A Nemoto, and
Y Tanaka, and
H Takagi, and
K Yazawa, and
Y Mikami, and
H Shigemori, and
J Kobayashi, and
A Ando, and
Y Nagata
Research Laboratory, Higeta Shoyu Co., Ltd., Choshi, Chiba, Japan.
A novel tricyclic diterpenoid antibiotic, brasilicardin A, was isolated from the culture broth of Nocardia brasiliensis IFM 0406. The antibiotic exhibited immunosuppressive activity in a mouse mixed lymphocyte reaction (MLR) assay system and its IC50 value was 0.057 microg/ml. Although the inhibitory activity of cyclosporin A (CyA) against IL-2 production was confirmed in the MLR assay system, brasilicardin A did not have the activity. The results of in vitro toxicity testing of brasilicardin A against various human cell lines were compared with those of CyA.
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