-transparent.png){kind=logo}
OBJECTIVE Trial of trimetasidine effects on exercise tolerance (ET) and left ventricular diastolic function (LVDF) in patients with coronary heart disease (CHD). METHODS The study group included 40 CHD patients. Of them 10, 18 and 12 had myocardial infarction, unstable angina pectoris and stable angina, respectively. 38 CHD patients of the control group had these disorders, respectively, in 5, 15 and 18 cases. 2-3-month therapy with nitrates, beta-blockers (BB) and inhibitors of angiotensin-converting enzyme (ACE) was given to both groups with adjuvant trimetasidine (60 mg/d) given to patients of the study group. The effects were judged by the results of cycle exercise tests and echo-CG including the loading one. RESULTS Adjuvant use of trimetasidine improved exercise tolerance, mean threshold capacity, LVDF. When added to BB treatment, trimetasidine reduced damage to LVDF under dipiridamol test. CONCLUSIONS Trimetasidine addition to combined treatment of CHD raises exercise tolerance and improves LVDF.
A D Kuimov, and
S D Maianskaia, and
E B Luksha, and
I I Volkova, and
V B Barbarich, and
S O Shliakhov, and
A V Iakovlev, and
A M Poliakova
January 2006,
Klinicheskaia meditsina,
A D Kuimov, and
S D Maianskaia, and
E B Luksha, and
I I Volkova, and
V B Barbarich, and
S O Shliakhov, and
A V Iakovlev, and
A M Poliakova
January 1986,
Catheterization and cardiovascular diagnosis,
A D Kuimov, and
S D Maianskaia, and
E B Luksha, and
I I Volkova, and
V B Barbarich, and
S O Shliakhov, and
A V Iakovlev, and
A M Poliakova
September 1985,
Zeitschrift fur Kardiologie,
A D Kuimov, and
S D Maianskaia, and
E B Luksha, and
I I Volkova, and
V B Barbarich, and
S O Shliakhov, and
A V Iakovlev, and
A M Poliakova
December 1999,
Cardiologia (Rome, Italy),
A D Kuimov, and
S D Maianskaia, and
E B Luksha, and
I I Volkova, and
V B Barbarich, and
S O Shliakhov, and
A V Iakovlev, and
A M Poliakova
August 2016,
Coronary artery disease,
A D Kuimov, and
S D Maianskaia, and
E B Luksha, and
I I Volkova, and
V B Barbarich, and
S O Shliakhov, and
A V Iakovlev, and
A M Poliakova
October 1987,
European heart journal,
A D Kuimov, and
S D Maianskaia, and
E B Luksha, and
I I Volkova, and
V B Barbarich, and
S O Shliakhov, and
A V Iakovlev, and
A M Poliakova
July 2018,
Zhonghua yi xue za zhi,
A D Kuimov, and
S D Maianskaia, and
E B Luksha, and
I I Volkova, and
V B Barbarich, and
S O Shliakhov, and
A V Iakovlev, and
A M Poliakova
April 1993,
Journal of the American College of Cardiology,
A D Kuimov, and
S D Maianskaia, and
E B Luksha, and
I I Volkova, and
V B Barbarich, and
S O Shliakhov, and
A V Iakovlev, and
A M Poliakova
October 1994,
Cardiovascular drugs and therapy,
A D Kuimov, and
S D Maianskaia, and
E B Luksha, and
I I Volkova, and
V B Barbarich, and
S O Shliakhov, and
A V Iakovlev, and
A M Poliakova
August 1985,
American heart journal,
