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16 patients with a Paget's disease at the age of 51--80 years were treated by synthetic salmon calcitonine in a dosis of 20 mcg (80 MRCU/die). 14 patients could be observed for a longer time. In all cases there was a statically significant decrease of the increased alkaline serum phosphatase. The excretion of hydroxyproline in the collected urine had a decreasing tendency. Other laboratory parameters as calcium, phosphatase and acid phosphatase in the serum and the excretion of calcium and phosphate in the urine were not significant influenced by therapy. The patients felt subjective a clear improvement of the bone pains. After a six month-treatment the dosis was reduced (each 2--7 days 20 mcg salmon calcitonin sc). There was observed a rebehaviour of the subjective symptoms and an increase of the alkaline serum phosphatase, which did not reach the unitial values before the beginning of treatment. Calcitonine is an effective substance for the treatment of an active Paget's disease.
U J Schmidt, and
K Trzenschik, and
K Abendroth, and
H Graner, and
A Ansorg
January 1975,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
U J Schmidt, and
K Trzenschik, and
K Abendroth, and
H Graner, and
A Ansorg
November 1977,
Pathologie-biologie,
U J Schmidt, and
K Trzenschik, and
K Abendroth, and
H Graner, and
A Ansorg
August 1980,
Wiener klinische Wochenschrift,
U J Schmidt, and
K Trzenschik, and
K Abendroth, and
H Graner, and
A Ansorg
August 1979,
Nihon Seikeigeka Gakkai zasshi,
U J Schmidt, and
K Trzenschik, and
K Abendroth, and
H Graner, and
A Ansorg
May 1976,
Casopis lekaru ceskych,
U J Schmidt, and
K Trzenschik, and
K Abendroth, and
H Graner, and
A Ansorg
November 1981,
Deutsche medizinische Wochenschrift (1946),
U J Schmidt, and
K Trzenschik, and
K Abendroth, and
H Graner, and
A Ansorg
December 1975,
British medical journal,
U J Schmidt, and
K Trzenschik, and
K Abendroth, and
H Graner, and
A Ansorg
September 1978,
Der Nervenarzt,
U J Schmidt, and
K Trzenschik, and
K Abendroth, and
H Graner, and
A Ansorg
July 1978,
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
U J Schmidt, and
K Trzenschik, and
K Abendroth, and
H Graner, and
A Ansorg
January 1980,
Acta chirurgica Belgica,
