-transparent.png){kind=logo}
To examine the relationship between the concentrations of urinary NAG and age, we measured ratios of urinary N-acetyl-beta-D-glucosaminidase (NAG) to urinary creatinine (NAG index) in 137 healthy subjects, aged from 19 to 88 years. The study is also designed to evaluate the relationship between urinary NAG and blood pressure. The subjects were divided into 7 subgroups, according to their age (< 30, 30-39, 40-49, 50-59, 60-69, 70-79, 80 or more years). There was a positive correlation between NAG index and age (r = 0.36; P < 0.001). The regression equation relating NAG index (y) to age (x) was y = 0.065x + 0.97. The mean NAG indexes for the 7 subgroups divided by age were significantly different (P < 0.01). There was a positive correlation between NAG index and systolic blood pressure (r = 0.18; P < 0.05), but was not between diastolic blood pressure and NAG index. In multiple regression analysis, age and BUN significantly correlated with NAG index (r = 0.32; P < 0.01, r = 3.3; P = 0.07, respectively), although there was no correlation between systolic blood pressure and NAG index. This cross-sectional study showed a clear elevation in NAG index with age. The rate of elevation was 0.65 per decade. Urinary excretion of NAG may be unrelated to blood pressure.
K Oba, and
M Hirai, and
Y Ajiro, and
K Okazaki, and
S Sato, and
K Sasai, and
T Suzuki, and
H Nakano, and
S Metori
January 1994,
Biology of the neonate,
K Oba, and
M Hirai, and
Y Ajiro, and
K Okazaki, and
S Sato, and
K Sasai, and
T Suzuki, and
H Nakano, and
S Metori
September 1980,
Archives of disease in childhood,
K Oba, and
M Hirai, and
Y Ajiro, and
K Okazaki, and
S Sato, and
K Sasai, and
T Suzuki, and
H Nakano, and
S Metori
February 1995,
Nihon rinsho. Japanese journal of clinical medicine,
K Oba, and
M Hirai, and
Y Ajiro, and
K Okazaki, and
S Sato, and
K Sasai, and
T Suzuki, and
H Nakano, and
S Metori
November 2004,
Nihon rinsho. Japanese journal of clinical medicine,
K Oba, and
M Hirai, and
Y Ajiro, and
K Okazaki, and
S Sato, and
K Sasai, and
T Suzuki, and
H Nakano, and
S Metori
August 1999,
Nihon rinsho. Japanese journal of clinical medicine,
K Oba, and
M Hirai, and
Y Ajiro, and
K Okazaki, and
S Sato, and
K Sasai, and
T Suzuki, and
H Nakano, and
S Metori
January 1988,
Biology of the neonate,
K Oba, and
M Hirai, and
Y Ajiro, and
K Okazaki, and
S Sato, and
K Sasai, and
T Suzuki, and
H Nakano, and
S Metori
February 1995,
Clinica chimica acta; international journal of clinical chemistry,
K Oba, and
M Hirai, and
Y Ajiro, and
K Okazaki, and
S Sato, and
K Sasai, and
T Suzuki, and
H Nakano, and
S Metori
January 1992,
Child nephrology and urology,
K Oba, and
M Hirai, and
Y Ajiro, and
K Okazaki, and
S Sato, and
K Sasai, and
T Suzuki, and
H Nakano, and
S Metori
December 1994,
Journal of paediatrics and child health,
K Oba, and
M Hirai, and
Y Ajiro, and
K Okazaki, and
S Sato, and
K Sasai, and
T Suzuki, and
H Nakano, and
S Metori
August 1989,
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie,
