Biomaterial Database

Effect of clomid, sexovid and prostaglandins on induction of ovulation and gonadotropin secretion in a freshwater catfish, Heteropneustes fossilis (Bloch). 1976

A K Singh, and T P Singh

The effect of clomid, sexovid and some prostaglandins (PGE1 and PGF2alpha) on the induction of ovulation, ovarian activity and gonadotropin concentration in the pituitary and blood serum was studied in H. fossilis. Sham-hypophysectomized individuals recorded a very high percentage (90--100%) of ovulation on the 6th day of clomid (150 mug), sexovid (150 mug), PGE1 (100 mug) and PGF2alpha (100 mug) administration. Amongst hypophysectomized recipients only sexovid treated ones ovulated (78%). These drugs were very effective in promoting the ovarian activity in intact specimens but, except sexovid, failed to stimulate any response in hypophysectomized subjects. The gonadotropin concentration in the pituitary gland and blood serum was also elevated after the treatment with the above compounds. It is quite evident from the data that clomid, PGE1, and PGF2alpha, probably acting via hypothalamus, accelerate the synthesis and release of gonadotropin which in turn induces hightened ovarian activity resulting in ovulation. Sexovid seems to have twofold action-- the one indirect through hypothalamus leads to hypophysis leads to ovary like clomid and prostaglandins, and the other directly upon the ovary, possibly by increasing its response to the available gonadotropin, or by behaving like LH.

UI	MeSH Term	Description	Entries
D007016	Hypophysectomy	Surgical removal or destruction of the hypophysis, or pituitary gland. (Dorland, 28th ed)	Hypophysectomies
D010060	Ovulation	The discharge of an OVUM from a rupturing follicle in the OVARY.	Ovulations
D011453	Prostaglandins	A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.	Prostaglandin,Prostanoid,Prostanoids
D011458	Prostaglandins E	(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.	PGE
D011460	Prostaglandins F	(9 alpha,11 alpha,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid (PGF(1 alpha)); (5Z,9 alpha,11,alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid (PGF(2 alpha)); (5Z,9 alpha,11 alpha,13E,15S,17Z)-9,11,15-trihydroxyprosta-5,13,17-trien-1-oic acid (PGF(3 alpha)). A family of prostaglandins that includes three of the six naturally occurring prostaglandins. All naturally occurring PGF have an alpha configuration at the 9-carbon position. They stimulate uterine and bronchial smooth muscle and are often used as oxytocics.	PGF
D002996	Clomiphene	A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue. Note that ENCLOMIPHENE and ZUCLOMIPHENE are the (E) and (Z) isomers of Clomiphene respectively.	Chloramiphene,Clomifene,Clomid,Clomide,Clomifen,Clomiphene Citrate,Clomiphene Hydrochloride,Clostilbegit,Dyneric,Gravosan,Klostilbegit,Serophene,Citrate, Clomiphene,Hydrochloride, Clomiphene
D003408	Cresols	Any of three isomeric crystalline aromatic methylphenols, also known as hydroxytoluenes.
D003506	Cyclofenil	A gonadal stimulant and inducer of ovulation. It is used in the treatment of infertility and amenorrhea, but is thought to be less effective than CLOMIPHENE.	4-((4-(Acetyloxy)phenyl)cyclohexylidenemethyl)phenol Acetate,Cyclophenil,F-6066,Ondogyne,F 6066,F6066
D005260	Female		Females
D005399	Fishes	A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.