Biomaterial Database

Effect of cyproterone acetate on the action and metabolism of testosterone in the mouse kidney. 1976

L Stárka, and J Sulcová, and P Broulík

Cyproterone acetate given alone or in combination with testosterone propionate or 5alpha-dihydrotestosterone to castrated male mice does not exhibit an antiandrogenic action on the kidney. It functions rather as a slightly renotropic hormone, even potentiating the renotropic activity of androgens. The administered amount of cyproterone acetate to intact males or castrates supplemented with androgens, however, decreased dramatically the weight of seminal vesicles and of spleen. Cyproterone acetate treatment of the animals influences in vitro the testosterone to androstenedione conversion but not the activity of 5alpha-reductase in the mouse kidney slices.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008297	Male		Males
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D002369	Castration	Surgical removal or artificial destruction of gonads.	Gonadectomy,Castrations,Gonadectomies
D003534	Cyproterone	An anti-androgen that, in the form of its acetate (CYPROTERONE ACETATE), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.	Cyproterone, 1alpha,2 alpha,9 beta,10 alpha-Isomer
D000734	Androstenediols	Unsaturated androstane derivatives which are substituted with two hydroxy groups in any position in the ring system.
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012669	Seminal Vesicles	A saclike, glandular diverticulum on each ductus deferens in male vertebrates. It is united with the excretory duct and serves for temporary storage of semen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Seminal Vesicle,Vesicle, Seminal,Vesicles, Seminal
D013154	Spleen	An encapsulated lymphatic organ through which venous blood filters.
D013739	Testosterone	A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.	17-beta-Hydroxy-4-Androsten-3-one,17-beta-Hydroxy-8 alpha-4-Androsten-3-one,8-Isotestosterone,AndroGel,Androderm,Andropatch,Androtop,Histerone,Sterotate,Sustanon,Testim,Testoderm,Testolin,Testopel,Testosterone Sulfate,17 beta Hydroxy 4 Androsten 3 one,17 beta Hydroxy 8 alpha 4 Androsten 3 one,8 Isotestosterone