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146 serial determinations of spontaneous and phytohemagglutinin-induced lymphocyte transformation as measured by tritiated thymidine incorporation, were performed in 24 healthy individuals. 9 persons were studied intensively during a mean period of 40 days and the other 15 underwent random investigations during a period up to 10 months. Transient episodes of significant decreased lymphocyte transformation were revealed in 14 persons (58.4%) with regard to the spontaneous blastogenesis and in 11 subjects (45.8%) with regard to PHA-induced reactivity. The occurrence of the decreased values in PHA responsiveness was significantly higher in the intensively studied group compared to the randomly investigated one (p = 0.001). The probability of detecting one low PHA-related response in a normal subject was 11%. In only half of the cultures with low spontaneous blastogenic response did a simultaneous decrease in PHA-induced lymphocyte transformation occur. In addition to the currently used stimulation index, a new index termed the Blastogenic Cumulative Index is proposed. It is defined as the sum of the logarithms of the dpm values of the spontaneous and the PHA induced lymphocyte transformation. The CI is suggested to describe lymphocyte blastogenic function more accurately, and due to its simplicity warrents further study. Other indices for lymphocyte blastogenesis determination are discussed.
A Bartal, and
T Mekori, and
R Haasz, and
Y Cohen, and
E Robinson
January 1973,
Verhandlungen der Deutschen Gesellschaft fur Innere Medizin,
A Bartal, and
T Mekori, and
R Haasz, and
Y Cohen, and
E Robinson
September 1986,
American journal of veterinary research,
A Bartal, and
T Mekori, and
R Haasz, and
Y Cohen, and
E Robinson
July 2005,
Nihon rinsho. Japanese journal of clinical medicine,
A Bartal, and
T Mekori, and
R Haasz, and
Y Cohen, and
E Robinson
June 1984,
Biology of reproduction,
A Bartal, and
T Mekori, and
R Haasz, and
Y Cohen, and
E Robinson
April 1972,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
A Bartal, and
T Mekori, and
R Haasz, and
Y Cohen, and
E Robinson
August 1968,
Canadian Medical Association journal,
A Bartal, and
T Mekori, and
R Haasz, and
Y Cohen, and
E Robinson
September 1967,
Canadian Medical Association journal,
A Bartal, and
T Mekori, and
R Haasz, and
Y Cohen, and
E Robinson
July 1969,
Saishin igaku. Modern medicine,
A Bartal, and
T Mekori, and
R Haasz, and
Y Cohen, and
E Robinson
September 1967,
Canadian Medical Association journal,
A Bartal, and
T Mekori, and
R Haasz, and
Y Cohen, and
E Robinson
November 1985,
Revista brasileira de biologia,
