BIOMAT Database Logo BIOMAT Database Logo

Aural cholesteatoma: role of tumor necrosis factor-alpha in bone destruction. 1999

K V Sastry, and S C Sharma, and S B Mann, and N K Ganguly, and N K Panda
Department of Otolaryngology and Head & Neck Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

OBJECTIVE The bone destruction in cholesteatoma is multifactorial. This study was undertaken to define the role of tumor necrosis factor-alpha (TNF-alpha) in bone destruction associated with cholesteatoma. BACKGROUND Tumor necrosis factor-alpha is an important inflammatory cytokine secreted by activated macrophages. It stimulates keratinocytes as an autocrine growth regulator. Few authors have localized TNF-alpha in aural cholesteatoma. An attempt was made in this study to show a correlation between TNF-alpha and cholesteatoma associated bone destruction by localizing TNF-alpha in cholesteatoma and measuring its serum level. METHODS Serum TNF-alpha levels were measured in 20 patients with cholesteatoma of temporal bone and histochemical staining was used to localize TNF-alpha in pathologic tissue excised at surgery. RESULTS Serum TNF-alpha levels in patients with cholesteatoma were significantly higher than in controls. In addition, TNF-alpha levels in patients with bone destruction were higher than in those without bone destruction. However, there was no correlation between age of the patient and serum TNF-alpha levels. The TNF-alpha was localized in various layers of cholesteatoma epithelium using indirect immunoperoxidase staining. CONCLUSIONS TNF-alpha is one of the cytokines produced by cholesteatoma that may be an important mediator of bone destruction associated with cholesteatoma. TNF-alpha has been localized in various layers of cholesteatoma and exerts a locally destructive effect on bone. Serum TNF-alpha levels are related to the extent of bone destruction.

UI MeSH Term Description Entries
D008297 Male Males
D001862 Bone Resorption Bone loss due to osteoclastic activity. Bone Loss, Osteoclastic,Osteoclastic Bone Loss,Bone Losses, Osteoclastic,Bone Resorptions,Loss, Osteoclastic Bone,Losses, Osteoclastic Bone,Osteoclastic Bone Losses,Resorption, Bone,Resorptions, Bone
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D004429 Ear Ossicles A mobile chain of three small bones (INCUS; MALLEUS; STAPES) in the TYMPANIC CAVITY between the TYMPANIC MEMBRANE and the oval window on the wall of INNER EAR. Sound waves are converted to vibration by the tympanic membrane then transmitted via these ear ossicles to the inner ear. Auditory Ossicles,Auditory Ossicle,Ear Ossicle,Ossicle, Auditory,Ossicle, Ear,Ossicles, Auditory,Ossicles, Ear
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D014409 Tumor Necrosis Factor-alpha Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS. Cachectin,TNF-alpha,Tumor Necrosis Factor Ligand Superfamily Member 2,Cachectin-Tumor Necrosis Factor,TNF Superfamily, Member 2,TNFalpha,Tumor Necrosis Factor,Cachectin Tumor Necrosis Factor,Tumor Necrosis Factor alpha
D018424 Cholesteatoma, Middle Ear A mass of KERATIN-producing squamous EPITHELIUM that resembles an inverted (suck-in) bag of skin in the MIDDLE EAR. It arises from the eardrum (TYMPANIC MEMBRANE) and grows into the MIDDLE EAR causing erosion of EAR OSSICLES and MASTOID that contains the INNER EAR. Middle Ear Cholesteatoma,Aural Cholesteatoma,Aural Cholesteatomas,Cholesteatoma, Aural,Cholesteatomas, Aural,Cholesteatomas, Middle Ear,Middle Ear Cholesteatomas

Related Publications

K V Sastry, and S C Sharma, and S B Mann, and N K Ganguly, and N K Panda
The role of tumor necrosis factor-alpha in bone resorption of cholesteatoma.
January 1991, American journal of otolaryngology,
K V Sastry, and S C Sharma, and S B Mann, and N K Ganguly, and N K Panda
The role of tumor necrosis factor-alpha (TNF-alpha) in bone resorption present in middle ear cholesteatoma.
January 2007, Brazilian journal of otorhinolaryngology,
K V Sastry, and S C Sharma, and S B Mann, and N K Ganguly, and N K Panda
Bone destruction due to the rupture of a cholesteatoma sac: a pathogenesis of bone destruction in aural-cholesteatoma.
November 1980, The Laryngoscope,
K V Sastry, and S C Sharma, and S B Mann, and N K Ganguly, and N K Panda
[A study on expression of tumor necrosis factor alpha in middle ear cholesteatoma and its effect on bone destruction].
February 2001, Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology,
K V Sastry, and S C Sharma, and S B Mann, and N K Ganguly, and N K Panda
Cartilage destruction and bone erosion in arthritis: the role of tumour necrosis factor alpha.
November 2000, Annals of the rheumatic diseases,
K V Sastry, and S C Sharma, and S B Mann, and N K Ganguly, and N K Panda
Role of tumor necrosis factor alpha in particulate-induced bone resorption.
January 1996, Journal of orthopaedic research : official publication of the Orthopaedic Research Society,
K V Sastry, and S C Sharma, and S B Mann, and N K Ganguly, and N K Panda
Essential role of tumor necrosis factor alpha.
September 2011, Retina (Philadelphia, Pa.),
K V Sastry, and S C Sharma, and S B Mann, and N K Ganguly, and N K Panda
[The expression of matrix metalloproteinase-9 and tumor necrosis factor-alpha in cholesteatoma].
July 2004, Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology,
K V Sastry, and S C Sharma, and S B Mann, and N K Ganguly, and N K Panda
Role of tumor necrosis factor alpha in asthma.
November 2004, Immunology and allergy clinics of North America,
K V Sastry, and S C Sharma, and S B Mann, and N K Ganguly, and N K Panda
[Role of tumor necrosis factor alpha in atherosclerosis].
January 2001, Archivos de cardiologia de Mexico,
Copied contents to your clipboard!