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The aim of this study was determination of IgG subclasses: IgG1, IgG2, IgG3 and IgG4 in children with atopic bronchial asthma and allergy rhinitis during long-term specific immunotherapy. The results showed in crease of IgG1 at first and next IgG4 subclasses. In our opinion it's a positive reaction of specific immunotherapy. Decrease of IgG2 and in less degree of IgG3 must be very carefully observation and analyse general in children with recurrent infections in the respiratory tract during specific immunotherapy.
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