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Neuroinvasion by human herpesvirus type 7 in a case of exanthem subitum with severe neurologic manifestations. 1999
J S van den Berg, and
J H van Zeijl, and
J J Rotteveel, and
W J Melchers, and
F J Gabreëls, and
J M Galama
Department of Child Neurology, University Hospital Nijmegen, The Netherlands.
A 19-month-old girl presented with severe neurologic symptoms associated with exanthem subitum. Human herpesvirus type 7 (HHV-7) DNA was detected in the CSF and serum, and supported by serologic studies. The patient was diagnosed with encephalopathy due to an acute HHV-7 infection. Neuron-specific enolase in the CSF was strongly elevated during the acute stage of infection, suggesting that the encephalopathy was due to viral invasion of the brain.
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