OBJECTIVE To compare the time savings and accuracy rates of a manual dispensing system with the Drug-O-Matic (DOM), an automated tablet and capsule counter. METHODS In part one, phase A of this two-part study, a time trial measured the time of the prescription-filling process using the manual method. In part one, phase B, a time trial measured the time of that process using the DOM system. Part two of the study measured the accuracy of the DOM. RESULTS The DOM requires 9 hours 42 minutes less per day than does the manual system. However, its accuracy causes some concern because we found a 14 percent discrepancy rate in terms of over- and underfills. CONCLUSIONS Our initial experience with the DOM suggests significant time-savings potential compared with the manual method of prescription filling, and our institutional goal is to translate the time saved into other activities that will allow us to function as a free-standing pharmacy. A concern is the DOM's 14 percent discrepancy rate. Further studies are needed to confirm or challenge our initial findings.