[Classification and pathogenesis of thrombohemorrhagic events connected with surgery. Intravascular coagulation in surgery]. 1976

A Doni

This disorders secondary to haemostasis which complicate surgery can be clinically subdivided into haemorrhagic and thrombotic complications. Haemorrhagic complication may present as a generalized haemorrhage that almost always occurs in the infra-operative period, or as a localized haemorrhage (mainly at the level of the gastroenteric tube). As this is seen in the postoperative period it can be defined as late. Thrombotic complication may present with a picture of phlebothrombosis, usually clinically evident at the lower extremities, or with a clinical picture of sudden occlusion of pulmonary circulation, namely pulmonary embolism. Pathogenetically, these two groups of complications may now be lumped together in view of the fact that surgery always causes stress in haemostatic function with thus reaches a condition of largely atent balance but which may be upset in either of two possible directions: hypohaemostatic or haemorrhagic on the one hand, and hyperhaemostatic and thrombotic on the other. The point in common is represented by the activation of the clotting system (platelet component included) followed or accompanied by anticlotting mechanisms (mainly the fibrinolytic). Whether the complication will be thrombotic or haemorrhagic depends on the prevalence of the former of the latter. These conclusions are based on an experimental clinical analysis of the phenomena that occur within the haemostatic function throughout the surgical process but principally at the operating stage itself, and are indirectly confirmed ex juvantibus in the proven effectiveness of heparinic prophylaxis. Therapeutic and prophylactic approaches are put forward on the basis of this unified pathogenetic concept.

UI MeSH Term Description Entries
D011183 Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery. Complication, Postoperative,Complications, Postoperative,Postoperative Complication
D001792 Blood Platelets Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation. Platelets,Thrombocytes,Blood Platelet,Platelet,Platelet, Blood,Platelets, Blood,Thrombocyte
D004211 Disseminated Intravascular Coagulation A disorder characterized by procoagulant substances entering the general circulation causing a systemic thrombotic process. The activation of the clotting mechanism may arise from any of a number of disorders. A majority of the patients manifest skin lesions, sometimes leading to PURPURA FULMINANS. Consumption Coagulopathy,Coagulation, Disseminated Intravascular,Disseminated Coagulation, Intravascular,Intravascular Coagulation, Disseminated,Intravascular Disseminated Coagulation,Coagulation, Intravascular Disseminated,Coagulations, Disseminated Intravascular,Coagulations, Intravascular Disseminated,Coagulopathies, Consumption,Coagulopathy, Consumption,Consumption Coagulopathies,Disseminated Coagulations, Intravascular,Disseminated Intravascular Coagulations,Intravascular Coagulations, Disseminated,Intravascular Disseminated Coagulations
D005342 Fibrinolysis The natural enzymatic dissolution of FIBRIN. Fibrinolyses
D006470 Hemorrhage Bleeding or escape of blood from a vessel. Bleeding,Hemorrhages
D006487 Hemostasis The process which spontaneously arrests the flow of BLOOD from vessels carrying blood under pressure. It is accomplished by contraction of the vessels, adhesion and aggregation of formed blood elements (eg. ERYTHROCYTE AGGREGATION), and the process of BLOOD COAGULATION. Hemostases
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013514 Surgical Procedures, Operative Operations carried out for the correction of deformities and defects, repair of injuries, and diagnosis and cure of certain diseases. (Taber, 18th ed.). Surgical Procedures,Ghost Surgery,Operative Procedures,Operative Surgical Procedure,Operative Surgical Procedures,Procedure, Operative Surgical,Procedures, Operative Surgical,Surgery, Ghost,Surgical Procedure, Operative,Operative Procedure,Procedure, Operative,Procedure, Surgical,Procedures, Operative,Procedures, Surgical,Surgical Procedure
D013927 Thrombosis Formation and development of a thrombus or blood clot in BLOOD VESSELS. Atherothrombosis,Thrombus,Blood Clot,Blood Clots,Thromboses

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