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In male Wistar rats PGF2alpha or PGE1 were injected intracerebroventricularly (icv) in a dose of 1 or 10 mug. Immediately or 1 hr after injection the locomotor and exploratory activity were measured. The levels of noradrenaline (NA), dopamine (DA) 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and acetylcholine (Ach) were measured in discrete brain areas. Both PGs applied ivc caused the depression of locomotor and exploratory activity in rats. PGE1 acted longer. Both substances but PGE1 more intensively affected the level of estimated biogenic amines in different brain structures. It is concluded that PGF2alpha and E1 are central nervous depressants. Both PGs affect neurons producing NA or 5-HT or Ach in discrete areas of brain in different manner. There is different susceptibility of brain structures on PGs action.
Z S Herman, and
K Kmieciak-Kolada, and
H L Wolny, and
J Slomińska-Zurek, and
A Bonczek
January 1977,
Archives for dermatological research = Archiv fur dermatologische Forschung,
Z S Herman, and
K Kmieciak-Kolada, and
H L Wolny, and
J Slomińska-Zurek, and
A Bonczek
January 1973,
Advances in the biosciences,
Z S Herman, and
K Kmieciak-Kolada, and
H L Wolny, and
J Slomińska-Zurek, and
A Bonczek
June 1975,
Obstetrics and gynecology,
Z S Herman, and
K Kmieciak-Kolada, and
H L Wolny, and
J Slomińska-Zurek, and
A Bonczek
February 1979,
Prostaglandins,
Z S Herman, and
K Kmieciak-Kolada, and
H L Wolny, and
J Slomińska-Zurek, and
A Bonczek
July 1974,
Surgical neurology,
Z S Herman, and
K Kmieciak-Kolada, and
H L Wolny, and
J Slomińska-Zurek, and
A Bonczek
May 1978,
The American journal of physiology,
Z S Herman, and
K Kmieciak-Kolada, and
H L Wolny, and
J Slomińska-Zurek, and
A Bonczek
December 1976,
Neuropharmacology,
Z S Herman, and
K Kmieciak-Kolada, and
H L Wolny, and
J Slomińska-Zurek, and
A Bonczek
July 1972,
Prostaglandins,
Z S Herman, and
K Kmieciak-Kolada, and
H L Wolny, and
J Slomińska-Zurek, and
A Bonczek
January 1975,
Farmakologiia i toksikologiia,
Z S Herman, and
K Kmieciak-Kolada, and
H L Wolny, and
J Slomińska-Zurek, and
A Bonczek
September 1973,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
