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The activity of adenosine deaminase (EC 3.5.4.4.) was significantly lower in lymphocytes from patients with lung cancer than in those from healthy subjects, whereas the activity of purine nucleoside phosphorylase (EC 2.4.2.1.) was significantly higher in lymphocytes from the patients than in those from normal controls. When the one activity was plotted against the other, the plots for patients with lung cancer were all outside the frame formed by the lower and higher limits of the standard deviation of the mean of normal activities of the two enzymes. The ratio of adenosine deaminase activity to purine nucleoside phosphorylase activity was lower in patients with lung cancer than in controls. The possible effect of this ratio on the function of lymphocytes was briefly discussed. These enzyme activities were suggested to be useful measures of the immune responsiveness of patients with lung cancer.
K Ogawa, and
K Tominaga, and
S Taoka, and
K Yata, and
E Tsubura
February 1981,
British journal of cancer,
K Ogawa, and
K Tominaga, and
S Taoka, and
K Yata, and
E Tsubura
January 1982,
Microbiology and immunology,
K Ogawa, and
K Tominaga, and
S Taoka, and
K Yata, and
E Tsubura
January 1982,
Microbiology and immunology,
K Ogawa, and
K Tominaga, and
S Taoka, and
K Yata, and
E Tsubura
January 1980,
Advances in experimental medicine and biology,
K Ogawa, and
K Tominaga, and
S Taoka, and
K Yata, and
E Tsubura
February 1983,
Clinical biochemistry,
K Ogawa, and
K Tominaga, and
S Taoka, and
K Yata, and
E Tsubura
November 1981,
Blood,
K Ogawa, and
K Tominaga, and
S Taoka, and
K Yata, and
E Tsubura
January 1984,
Advances in experimental medicine and biology,
K Ogawa, and
K Tominaga, and
S Taoka, and
K Yata, and
E Tsubura
January 1982,
Leukemia research,
K Ogawa, and
K Tominaga, and
S Taoka, and
K Yata, and
E Tsubura
April 1980,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
K Ogawa, and
K Tominaga, and
S Taoka, and
K Yata, and
E Tsubura
August 1977,
Nihon rinsho. Japanese journal of clinical medicine,
