-transparent.png){kind=logo}
Effect of the additional treatment with coenzyme Q10 on immunorestoration with Mycobacterium bovis BCG in tumor-bearing mice was investigated. Cell-mediated cytotoxicity in tumor-bearing mice against alloantigenic tumor cells was determined by 51Cr release assay using spleen cells of C57BL/6N mice which had been inoculated subcutaneously with syngeneic melanoma-B16 and immunized intraperitoneally with alloantigenic mastocytoma P815-X2 cells. The cell-mediated cytotoxicity against mastocytoma P815-X2 cells was gradually depressed with the growth of melanoma-B16. The depressed, cell-mediated cytotoxicity in tumor-bearing mice recovered slightly by the treatment with BCG. The recovery effect of BCG on the depressed, cell-mediated cytotoxicity was significantly enhanced by the additional treatment with coenzyme Q10. Coenzyme Q10 did not have an apparent effect on the depressed, cell-mediated cytotoxicity in tumor-bearing mice. These results show that coenzyme Q10 enhances the immunorestoration with BCG in tumor-bearing mice.
I Kawase, and
H Niitani, and
N Saijo, and
H Sasaki, and
T Morita
December 1975,
Gan,
I Kawase, and
H Niitani, and
N Saijo, and
H Sasaki, and
T Morita
July 1987,
Infection and immunity,
I Kawase, and
H Niitani, and
N Saijo, and
H Sasaki, and
T Morita
June 1986,
Tubercle,
I Kawase, and
H Niitani, and
N Saijo, and
H Sasaki, and
T Morita
June 1977,
Journal of immunology (Baltimore, Md. : 1950),
I Kawase, and
H Niitani, and
N Saijo, and
H Sasaki, and
T Morita
June 1974,
Journal of the National Cancer Institute,
I Kawase, and
H Niitani, and
N Saijo, and
H Sasaki, and
T Morita
October 1981,
The American journal of pathology,
I Kawase, and
H Niitani, and
N Saijo, and
H Sasaki, and
T Morita
December 1972,
National Cancer Institute monograph,
I Kawase, and
H Niitani, and
N Saijo, and
H Sasaki, and
T Morita
February 2010,
Journal of medicinal food,
I Kawase, and
H Niitani, and
N Saijo, and
H Sasaki, and
T Morita
September 1981,
Biken journal,
I Kawase, and
H Niitani, and
N Saijo, and
H Sasaki, and
T Morita
December 1972,
National Cancer Institute monograph,
