Biomaterial Database

[Effect of kynurenine and its metabolites on the concentration of 11-hydroxycorticosteroids in rat plasma]. 1976

I P Lapin, and I B Prakh'e, and R A Khaunina

Injections of kynurenine (10 and 25 mg/kg, i.p.) and nicotinic acid (50 mg/kg i.p.) produced a marked increase in concentration of 11-hydroxycorticosteroids (11-HCS) in rat blood plasma. Effect of nicotinic acid was not prevented by dexamethazone (0.6 mg/kg). Subtreshold dose of nicotinic acid (10 mg/kg) enhanced a rise in 11-HCS produced by swimming stress. 3-hydroxykynurenine, 3-hydroxyanthranilic, antranilic picolinic and quinolinic acids (10-50 mg/kg) did not change the concentration of 11-HCS. It is suggested that some of the biochemical and pharmacological effects of injected kynurenine can be mediated through the rise of 11-HCS in blood.

UI	MeSH Term	Description	Entries
D007737	Kynurenine	A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway.
D008297	Male		Males
D009539	Nicotinic Acids	2-, 3-, or 4-Pyridinecarboxylic acids. Pyridine derivatives substituted with a carboxy group at the 2-, 3-, or 4-position. The 3-carboxy derivative (NIACIN) is active as a vitamin.	Acids, Nicotinic
D010848	Picolinic Acids	Compounds with general formula C5H4N(CO2H) derived from PYRIDINE, having a carboxylic acid substituent at the 2-position.	Acids, Picolinic
D011805	Quinolinic Acids	Dicarboxylic acids with a PYRIDINE backbone. Quinolinic Acids are downstream products of the KYNURENINE pathway which metabolize amino acid TRYPTOPHAN.	Acids, Quinolinic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D015062	11-Hydroxycorticosteroids	A group of corticosteroids bearing a hydroxy group at the 11-position.	11 Hydroxycorticosteroids
D015095	3-Hydroxyanthranilic Acid	An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen.	3 Hydroxyanthranilic Acid,Acid, 3-Hydroxyanthranilic
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D062367	ortho-Aminobenzoates	Benzoic acids, salts, or esters that contain an amino group attached to carbon number 2 or 6 of the benzene ring structure.	2-Aminobenzoates,6-Aminobenzoates,Anthranilates,Anthranilic Acids,o-Aminobenzoates,o-Aminobenzoic Acids,ortho-Aminobenzoic Acids,6 Aminobenzoates,Acids, Anthranilic,Acids, o-Aminobenzoic,Acids, ortho-Aminobenzoic,o Aminobenzoates,o Aminobenzoic Acids,ortho Aminobenzoates,ortho Aminobenzoic Acids