[Tissue-plasminogen-activators of maternal and fetal rat lungs after application of betamethasone or bromhexine-metabolite VIII (author's transl)]. 1976

S Haas-Denk, and P Krieglsteiner, and I Wriedt-Lübbe, and W Erhardt, and W Münnich, and G Blümel

Prenatal RDS-prevention is currently done by two substances: Corticosteroids and Bromhexine Metabolit VIII. The influence on fibrinolytic activity of these drugs in the fetal rat-lung was tested in vivo. The inhibitory effect against tissue-fibrinogen-activator of Beta-methason was greater than this of Bromhexine Metabolit VIII.

UI MeSH Term Description Entries
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D010960 Plasminogen Activators A heterogeneous group of proteolytic enzymes that convert PLASMINOGEN to FIBRINOLYSIN. They are concentrated in the lysosomes of most cells and in the vascular endothelium, particularly in the vessels of the microcirculation. Extrinsic Plasminogen Activators,Plasminogen Activator,Uterine-Tissue Plasminogen Activator,Uterine Tissue Plasminogen Activator
D001964 Bromhexine A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744) Aparsonin,Bisolvon,Bromhexin,Bromhexin BC,Bromhexin Berlin-Chemie,Bromhexin-ratiopharm,Bromhexine Hydrochloride,Bromhexine Monohydrochloride,Brotussol,Darolan,Dur-Elix,Famel Bromhexine,Flegamin,Flubron,Hustentabs-ratiopharm,Mucohexine,NA-274,Quentan,Tesacof,bromhexin von ct,BC, Bromhexin,Bromhexin Berlin Chemie,Bromhexin BerlinChemie,Bromhexin ratiopharm,Bromhexine, Famel,Bromhexinratiopharm,Dur Elix,DurElix,Hustentabs ratiopharm,Hustentabsratiopharm,Hydrochloride, Bromhexine,Monohydrochloride, Bromhexine,NA 274,NA274,ct, bromhexin von,von ct, bromhexin
D005342 Fibrinolysis The natural enzymatic dissolution of FIBRIN. Fibrinolyses
D000551 Ambroxol A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride. Bromhexine Metabolite VIII,4-(((2-Amino-3,5-dibromophenyl)methyl)amino)cyclohexanol,AMBROPP,Abrohexal,Ambril,Ambro-Puren,Ambrobeta,Ambrofur,Ambrohexal,Ambrolitic,Ambrolös,Ambroten,Ambroxin,Ambroxocompren,Bisolvon AM,Bronchopront,Bronchowern,Broxol,Contac Husten-Trunk,Dinobroxol,Duramucal,Ebromin,Expeflen,Expit,Farmabroxol,Flavamed,Frenopect,Gelopol,Larylin Husten-Löser,Lasolvan,Mibrox,Motosol,Muco-Fips,Mucosolvan,Mucotablin,NA-872,Pect Hustenlöser,Pulmonal S,Pädiamuc,Ringelheimer Pulmonal,Sekretovit,Surbronc,Therapin Hustenlöser,stas-Hustenlöser,AM, Bisolvon,Ambro Puren,AmbroPuren,Contac Husten Trunk,Contac HustenTrunk,Hustenlöser, Pect,Hustenlöser, Therapin,Larylin Husten Löser,Larylin HustenLöser,Metabolite VIII, Bromhexine,Muco Fips,MucoFips,NA 872,NA872,Pulmonal, Ringelheimer,stas Hustenlöser,stasHustenlöser
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001623 Betamethasone A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724) Betadexamethasone,Flubenisolone,Celeston,Celestona,Celestone,Cellestoderm
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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