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A systematic microscopic examination of all elements of the capillary wall was performed on quadriceps muscle biopsies from 9 diabetic patients and 8 controls. The capillary basement membrane (CBM) was markedly thicker in diabetics; it consisted of several lamellae and contained large vacuoles which were never observed in non-diabetic subjects. Large magnifications revealed fibrils in greater number and markedly larger in diameter in diabetics, these accounting for a considerable volume of the CBM and the adventitia and increased diameter and thickness of the capillary wall, without encroaching on the lumen. The intracellular fibrils in pericytes and endothelial cells were also larger and thicker in diabetic subjects. The prevalence of fibrillar material in the vascular disease of diabetes mellitus suggests the importance of research into possible measures to arrest fibril formation.
M Ravid, and
R Silman-Socher, and
Y Ben Shaul, and
E Sohar
December 1966,
Laboratory investigation; a journal of technical methods and pathology,
M Ravid, and
R Silman-Socher, and
Y Ben Shaul, and
E Sohar
May 1971,
Journees annuelles de diabetologie de l'Hotel-Dieu,
M Ravid, and
R Silman-Socher, and
Y Ben Shaul, and
E Sohar
January 1964,
Frankfurter Zeitschrift fur Pathologie,
M Ravid, and
R Silman-Socher, and
Y Ben Shaul, and
E Sohar
January 1963,
Diabetes,
M Ravid, and
R Silman-Socher, and
Y Ben Shaul, and
E Sohar
October 1988,
Mechanisms of ageing and development,
M Ravid, and
R Silman-Socher, and
Y Ben Shaul, and
E Sohar
October 1965,
Arkhiv anatomii, gistologii i embriologii,
M Ravid, and
R Silman-Socher, and
Y Ben Shaul, and
E Sohar
January 1985,
Experimental pathology,
M Ravid, and
R Silman-Socher, and
Y Ben Shaul, and
E Sohar
July 1984,
Morphologiai es igazsagugyi orvosi szemle,
M Ravid, and
R Silman-Socher, and
Y Ben Shaul, and
E Sohar
January 1979,
Arkhiv anatomii, gistologii i embriologii,
M Ravid, and
R Silman-Socher, and
Y Ben Shaul, and
E Sohar
January 1980,
Oftalmologicheskii zhurnal,
