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The bile acid-base parameters are analyzed in 42 male Wistar rats under pentobarbital anaesthesia, in normal conditions of blood acid-base equilibrium. The reproducibility of the results is emphasized. In acute hypercapnia (FICO2 : 0.12 for 15 min) without hypoxia, and for the same increase in PCO2, and pH variation is lesser in bile than in blood, thus showing an high buffer capacity. In vitro and in vivo comparative studies show that bile buffer capacity is about five times higher in vivo, independently of a possible increase in choleresis. Comparative studies of bile-acid-base equilibrium are effected during perfusions of dehydrocholate, sodium taurocholate, secretin and acetazolamide. Sodium and chlorine remain stable during hypercapnia both in blood and in bile ; potassium concentration is increased in the two media. To explain these results, the role of the liver is still to specify.
F Guerrin, and
H Robin, and
B Louf
January 1975,
Bulletin de physio-pathologie respiratoire,
F Guerrin, and
H Robin, and
B Louf
January 1976,
Bulletin europeen de physiopathologie respiratoire,
F Guerrin, and
H Robin, and
B Louf
January 1978,
Arzneimittel-Forschung,
F Guerrin, and
H Robin, and
B Louf
January 1980,
Respiration; international review of thoracic diseases,
F Guerrin, and
H Robin, and
B Louf
August 1980,
Leber, Magen, Darm,
F Guerrin, and
H Robin, and
B Louf
September 1975,
Langenbecks Archiv fur Chirurgie,
F Guerrin, and
H Robin, and
B Louf
September 1980,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
F Guerrin, and
H Robin, and
B Louf
January 1976,
Bulletin europeen de physiopathologie respiratoire,
F Guerrin, and
H Robin, and
B Louf
August 1980,
Zhonghua wai ke za zhi [Chinese journal of surgery],
F Guerrin, and
H Robin, and
B Louf
October 1978,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
