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Synthesis and transport of proteins to the cell nucleus during puff induction was studied in S. coprophila. Changes in grain distribution along chromosomes (L-methionine [35S] incorporation into protein) were correlated with puffs induced by ecdysterone in vitro; A pattern of specific labelling at the sites of incipient puffs was noted within 2 h after the addition of the hormone, i.e. grains on the chromosomes were in clusters, characteristic for this time point and not seen in the controls (where only non-specific labeling was noted 0-4 h). Characteristic chromosomal puffs appeared between 3-4 h after the addition of ecdysterone. It was concluded that during ecdysterone-induced puff formation in salivary gland chromosomes, proteins which had been previously synthesized were selectively transported from the cytoplasm to specific sites on the chromosomes.
R M Goodman, and
E C Schmidt, and
W B Benjamin
August 1964,
Chromosoma,
R M Goodman, and
E C Schmidt, and
W B Benjamin
March 1973,
Experimental cell research,
R M Goodman, and
E C Schmidt, and
W B Benjamin
January 1972,
Chromosoma,
R M Goodman, and
E C Schmidt, and
W B Benjamin
February 1935,
Proceedings of the National Academy of Sciences of the United States of America,
R M Goodman, and
E C Schmidt, and
W B Benjamin
August 1937,
Proceedings of the National Academy of Sciences of the United States of America,
R M Goodman, and
E C Schmidt, and
W B Benjamin
July 1936,
Genetics,
R M Goodman, and
E C Schmidt, and
W B Benjamin
June 2009,
Chromosoma,
R M Goodman, and
E C Schmidt, and
W B Benjamin
November 1972,
The Journal of cell biology,
R M Goodman, and
E C Schmidt, and
W B Benjamin
December 1934,
Proceedings of the National Academy of Sciences of the United States of America,
R M Goodman, and
E C Schmidt, and
W B Benjamin
April 1965,
Journal of cellular physiology,
