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As there are only a finite number of materials suitable for orthopaedic reconstruction, considerable effort has been devoted recently to investigating ways of altering the surface chemistry of prosthetic materials without altering their bulk properties. Ion beam implantation is one such technique which is appropriate for orthopaedic reconstructive materials. This paper investigates the early effect of ion beam modification on cellular attachment of bone derived cells using a prototype device which measures the strength of attachment of individual cells to a silicon substratum. The results point to several conclusions. (1) There is no evidence that ion beam implantation with nitrogen, phosphorus, manganese or magnesium produces increased adhesion of human bone derived cells. (2) Surface etching with hydrofluoric acid, electron bombardment and thermal oxidation increases the strength of attachment between cells and substrata. (3) There is a correlation between wettability and rate of cellular attachment to oxygen implanted substrata during the first 2 h after cellular seeding. However, the increase in cellular attachment cannot be entirely explained by the change in critical surface tension or via increased fibronectin attachment to the substrata.
C R Howlett, and
M D Evans, and
K L Wildish, and
J C Kelly, and
L R Fisher, and
G W Francis, and
D J Best
October 2003,
Yao xue xue bao = Acta pharmaceutica Sinica,
C R Howlett, and
M D Evans, and
K L Wildish, and
J C Kelly, and
L R Fisher, and
G W Francis, and
D J Best
December 2011,
Clinical oral implants research,
C R Howlett, and
M D Evans, and
K L Wildish, and
J C Kelly, and
L R Fisher, and
G W Francis, and
D J Best
July 2007,
Journal of cell science,
C R Howlett, and
M D Evans, and
K L Wildish, and
J C Kelly, and
L R Fisher, and
G W Francis, and
D J Best
April 2006,
Biological research for nursing,
C R Howlett, and
M D Evans, and
K L Wildish, and
J C Kelly, and
L R Fisher, and
G W Francis, and
D J Best
December 1986,
Physical review. B, Condensed matter,
C R Howlett, and
M D Evans, and
K L Wildish, and
J C Kelly, and
L R Fisher, and
G W Francis, and
D J Best
September 2008,
Journal of materials science. Materials in medicine,
C R Howlett, and
M D Evans, and
K L Wildish, and
J C Kelly, and
L R Fisher, and
G W Francis, and
D J Best
December 1990,
Journal of theoretical biology,
C R Howlett, and
M D Evans, and
K L Wildish, and
J C Kelly, and
L R Fisher, and
G W Francis, and
D J Best
December 2004,
The Journal of arthroplasty,
C R Howlett, and
M D Evans, and
K L Wildish, and
J C Kelly, and
L R Fisher, and
G W Francis, and
D J Best
December 2002,
Cell research,
C R Howlett, and
M D Evans, and
K L Wildish, and
J C Kelly, and
L R Fisher, and
G W Francis, and
D J Best
August 2008,
Journal of nanoscience and nanotechnology,
