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Some recent studies from Japan on liver dye metabolism are presented. Special attention has been given to 17 cases of constitutional indocyamine green retention syndrome. This syndrome consists of marked ICG-retention and normal BSP excretion. Other liver function tests such as enzymes or serum fractions are normal. In liver biopsy specimens there are no significant abnormal findings. The cause of the syndrome is still unknown but disturbance of passage through the membrane is considered. So far, this syndrome has only been noted in Japan.
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