BIOMAT Database Logo BIOMAT Database Logo

Twenty-four hour ambulatory nasal pH monitoring. 1999

S S Hehar, and J D Mason, and A B Stephen, and N Washington, and N S Jones, and S J Jackson, and D Bush
Department of Otorhinolaryngology/Head and Neck Surgery, University Hospital, Nottingham, UK.

The nasal delivery of drugs, both for systemic and local use, is an expanding field with many drugs being delivered by this route. It is known that changes in pH can affect drug absorption but there is no data regarding intranasal pH over time. We present the results of 24-h ambulatory nasal pH monitoring in four subjects, each of whom had monitoring on two separate occasions. The apparatus consisted of a pH monitor with two electrodes, thus enabling us to take readings from 1 and 4 cm behind the anterior end of the inferior turbinate. Measurements were recorded every 6 s by the posterior electrode and every 30 s by the anterior electrode. The recording apparatus was worn around the subjects waist. Analysis of the results showed that there was no diurnal variation and no significant differences between the subjects. The mean pH from the anterior electrode was higher than that from the posterior (7.1 versus 6.6). The pH did not fluctuate with daily activities such as eating, drinking or sleeping. The results are interesting and may be of importance with regard to the design of formulations for nasal drug delivery systems.

UI MeSH Term Description Entries
D008297 Male Males
D009296 Nasal Cavity The proximal portion of the respiratory passages on either side of the NASAL SEPTUM. Nasal cavities, extending from the nares to the NASOPHARYNX, are lined with ciliated NASAL MUCOSA. Nasal Cavities,Cavities, Nasal,Cavity, Nasal
D009297 Nasal Mucosa The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells. Nasal Epithelium,Schneiderian Membrane,Epithelium, Nasal,Membrane, Schneiderian,Mucosa, Nasal
D002940 Circadian Rhythm The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli. Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006863 Hydrogen-Ion Concentration The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D000203 Activities of Daily Living The performance of the basic activities of self care, such as dressing, ambulation, or eating. ADL,Chronic Limitation of Activity,Limitation of Activity, Chronic,Activities, Daily Living,Activity, Daily Living,Daily Living Activities,Daily Living Activity,Living Activities, Daily,Living Activity, Daily
D000281 Administration, Intranasal Delivery of medications through the nasal mucosa. Drug Administration, Intranasal,Administration, Intranasal Drug,Administration, Nasal,Intranasal Administration,Intranasal Drug Administration,Administrations, Intranasal,Administrations, Intranasal Drug,Administrations, Nasal,Drug Administrations, Intranasal,Intranasal Administrations,Intranasal Drug Administrations,Nasal Administration,Nasal Administrations
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

S S Hehar, and J D Mason, and A B Stephen, and N Washington, and N S Jones, and S J Jackson, and D Bush
Twenty-four-hour ambulatory oesophageal pH monitoring.
August 1987, The British journal of surgery,
S S Hehar, and J D Mason, and A B Stephen, and N Washington, and N S Jones, and S J Jackson, and D Bush
Twenty-four hour ambulatory oesophageal pH monitoring: an update.
March 1987, The British journal of surgery,
S S Hehar, and J D Mason, and A B Stephen, and N Washington, and N S Jones, and S J Jackson, and D Bush
Twenty-four-hour ambulatory oesophageal pH monitoring: experience in The Netherlands.
March 1989, The Netherlands journal of medicine,
S S Hehar, and J D Mason, and A B Stephen, and N Washington, and N S Jones, and S J Jackson, and D Bush
Twenty-four hour intraesophageal pH monitoring.
December 1986, Gastroenterology,
S S Hehar, and J D Mason, and A B Stephen, and N Washington, and N S Jones, and S J Jackson, and D Bush
Twenty-four-hour ambulatory blood pressure monitoring.
December 2022, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne,
S S Hehar, and J D Mason, and A B Stephen, and N Washington, and N S Jones, and S J Jackson, and D Bush
Twenty-Four-Hour Ambulatory Blood Pressure Monitoring.
January 2020, Journal of primary care & community health,
S S Hehar, and J D Mason, and A B Stephen, and N Washington, and N S Jones, and S J Jackson, and D Bush
[Twenty-four hour ambulatory blood pressure monitoring].
November 2005, Deutsche medizinische Wochenschrift (1946),
S S Hehar, and J D Mason, and A B Stephen, and N Washington, and N S Jones, and S J Jackson, and D Bush
Twenty-four-hour ambulatory electrocardiographic monitoring of surgeons.
January 1995, International surgery,
S S Hehar, and J D Mason, and A B Stephen, and N Washington, and N S Jones, and S J Jackson, and D Bush
Twenty four hour intermittent, ambulatory blood pressure monitoring.
November 1987, Archives of disease in childhood,
S S Hehar, and J D Mason, and A B Stephen, and N Washington, and N S Jones, and S J Jackson, and D Bush
Twenty-four hour ambulatory pH recording with computerised analysis.
November 1984, Medical & biological engineering & computing,
Copied contents to your clipboard!