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[Increased sensitivity to cockroaches of the species Blattella germanica in patients with allergic diseases]. 1999

V B Gerbazieva, and S N Zhirova, and V V Sveranovskaia

Sensitization to Blattella germanica (B.g.) was studied in 290 allergic patients having increased sensitivity to house dust (HD). The study carried out by ELISA techniques with the use of allergen especially developed by the authors, revealed that the sera of adults and children with bronchial asthma (BA) contained high levels of IgE antibodies (Ab) to B.g. in 34 and 63.5% of cases, respectively. The presence of pronounced IgE-linked sensitization of target cells of BA patients was confirmed in leukocyte alteration test and in the natural leukocyte migration inhibition test. Increased sensitization to B.g. was shown to be the second in the total spectrum of sensitization to different arthropod species in house dust, and the presence of mixed sensitization to B.g. and HD mites was not due to cross reactions caused by main mite allergens. The content of IgG and IgG4 Ab to B.g. in BA patients exceeds that in healthy subjects, the tendency towards reverse correlation (r = -0.4) between the content of specific IgE and IgG Ab being revealed in the former. An essential role of sensitization to cockroaches in pathogenesis of BA is emphasized.

UI MeSH Term Description Entries
D006967 Hypersensitivity Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen. Allergy,Allergic Reaction,Allergic Reactions,Allergies,Hypersensitivities,Reaction, Allergic,Reactions, Allergic
D007073 Immunoglobulin E An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE). IgE
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007223 Infant A child between 1 and 23 months of age. Infants
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D004391 Dust Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed) House Dust,Housedust,Dust, House
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths

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