BIOMAT Database Logo BIOMAT Database Logo

Hemodynamic effects of fluid loading in acute massive pulmonary embolism. 1999

A Mercat, and J L Diehl, and G Meyer, and J L Teboul, and H Sors
Medical ICU, Hopital de Bicêtre, Université Paris XI, France.

OBJECTIVE To assess the hemodynamic effects of fluid loading in patients with acute circulatory failure caused by acute massive pulmonary embolism (AMPE). METHODS Prospective study. METHODS Respiratory critical care unit of a university hospital. METHODS Thirteen patients free of previous cardiopulmonary disease with angiographically proven AMPE (Miller index = 24 +/- 1), with acute circulatory failure defined by a cardiac index (CI) lower than 2.5 L/min/m2. METHODS Infusion of 500 mL of dextran 40 over 20 mins. RESULTS Fluid loading induced a substantial increase in right atrial pressure from 9 +/- 1 mm Hg to 17 +/- 1 mm Hg and in right ventricular end-diastolic volume index from 123 +/- 14 mL/m2 to 150 +/- 11 mL/m2 (p < .05 for both comparisons). The increase in right ventricular preload was associated with an increase in Cl from 1.6 +/- 0.1 to 2.0 +/- 0.1 L/min/m2 (p < .05), whereas right ventricular ejection fraction (15 +/- 3% at baseline vs. 16 +/- 3% after fluid loading) and total pulmonary vascular resistance index (1689 +/- 187 dyne x sec/cm5 x m2 at baseline vs. 1492 +/- 166 dyne x sec/ cm5 x m2 after fluid loading) remained unchanged. The increase in Cl induced by fluid loading was inversely correlated to baseline right ventricular end-diastolic volume index (r = -.89 ; p< .05). CONCLUSIONS These results suggest that fluid loading can improve hemodynamic status in patients with acute circulatory failure caused by AMPE.

UI MeSH Term Description Entries
D007262 Infusions, Intravenous The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it. Drip Infusions,Intravenous Drip,Intravenous Infusions,Drip Infusion,Drip, Intravenous,Infusion, Drip,Infusion, Intravenous,Infusions, Drip,Intravenous Infusion
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010952 Plasma Substitutes Any liquid used to replace blood plasma, usually a saline solution, often with serum albumins, dextrans or other preparations. These substances do not enhance the oxygen- carrying capacity of blood, but merely replace the volume. They are also used to treat dehydration. Blood Expanders,Plasma Volume Expanders,Expanders, Blood,Expanders, Plasma Volume,Substitutes, Plasma,Volume Expanders, Plasma
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D011655 Pulmonary Embolism Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS. Pulmonary Thromboembolism,Thromboembolism, Pulmonary,Embolism, Pulmonary,Embolisms, Pulmonary,Pulmonary Embolisms,Pulmonary Thromboembolisms,Thromboembolisms, Pulmonary
D003422 Critical Care Health care provided to a critically ill patient during a medical emergency or crisis. Intensive Care,Intensive Care, Surgical,Surgical Intensive Care,Care, Critical,Care, Intensive,Care, Surgical Intensive
D003911 Dextrans A group of glucose polymers made by certain bacteria. Dextrans are used therapeutically as plasma volume expanders and anticoagulants. They are also commonly used in biological experimentation and in industry for a wide variety of purposes. Dextran,Dextran 40,Dextran 40000,Dextran 70,Dextran 75,Dextran 80,Dextran B-1355,Dextran B-1355-S,Dextran B1355,Dextran B512,Dextran Derivatives,Dextran M 70,Dextran T 70,Dextran T-40,Dextran T-500,Hemodex,Hyskon,Infukoll,Macrodex,Polyglucin,Promit,Rheodextran,Rheoisodex,Rheomacrodex,Rheopolyglucin,Rondex,Saviosol,Dextran B 1355,Dextran B 1355 S,Dextran T 40,Dextran T 500
D005440 Fluid Therapy Therapy whose basic objective is to restore the volume and composition of the body fluids to normal with respect to WATER-ELECTROLYTE BALANCE. Fluids may be administered intravenously, orally, by intermittent gavage, or by HYPODERMOCLYSIS. Oral Rehydration Therapy,Rehydration,Rehydration, Oral,Oral Rehydration,Rehydration Therapy, Oral,Therapy, Fluid,Therapy, Oral Rehydration,Fluid Therapies,Oral Rehydration Therapies,Oral Rehydrations,Rehydration Therapies, Oral,Rehydrations,Rehydrations, Oral,Therapies, Fluid,Therapies, Oral Rehydration
D006439 Hemodynamics The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM. Hemodynamic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

A Mercat, and J L Diehl, and G Meyer, and J L Teboul, and H Sors
The hemodynamic response to isoproterenol in massive acute pulmonary embolism.
January 1969, Israel journal of medical sciences,
A Mercat, and J L Diehl, and G Meyer, and J L Teboul, and H Sors
[Hemodynamic reactions in acute period of massive embolism of pulmonary arteries].
May 1997, Biulleten' eksperimental'noi biologii i meditsiny,
A Mercat, and J L Diehl, and G Meyer, and J L Teboul, and H Sors
Pharmacologic hemodynamic support in massive pulmonary embolism.
January 1997, Chest,
A Mercat, and J L Diehl, and G Meyer, and J L Teboul, and H Sors
RETRACTED: ST-elevation in massive acute pulmonary embolism during hemodynamic instability.
January 2018, Journal of electrocardiology,
A Mercat, and J L Diehl, and G Meyer, and J L Teboul, and H Sors
[Acute massive pulmonary embolism].
April 2005, Orvosi hetilap,
A Mercat, and J L Diehl, and G Meyer, and J L Teboul, and H Sors
Pulmonary embolism, massive, acute.
September 1949, The New England journal of medicine,
A Mercat, and J L Diehl, and G Meyer, and J L Teboul, and H Sors
Hemodynamic effects of amrinone in a canine model of massive pulmonary embolism.
July 1992, Chest,
A Mercat, and J L Diehl, and G Meyer, and J L Teboul, and H Sors
The use of hemodynamic support in massive pulmonary embolism.
September 2017, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions,
A Mercat, and J L Diehl, and G Meyer, and J L Teboul, and H Sors
Effects of volume loading during experimental acute pulmonary embolism.
July 1989, Circulation,
A Mercat, and J L Diehl, and G Meyer, and J L Teboul, and H Sors
Acute massive pulmonary embolism with hemodynamic compromise treated successfully with thrombolytic therapy.
December 2009, Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis,
Copied contents to your clipboard!