Biomaterial Database

Effects of lead on the male reproductive system in mice. 1999

S A Wadi, and G Ahmad

Department of Biology, Seton Hall University, South Orange, New Jersey 07079-2694, USA.

The effect of environmental lead on the male reproductive system has been a major area of concern for several years. Lead toxicity to the male reproductive system of sexually mature male CF-1 mice was investigated by administering two concentrations of lead (0.25% and 0.5%) via drinking water for 6 wk. The low lead dose significantly reduced the number of sperm within the epididymis, while the high dose reduced both the sperm count and percentage of motile sperm and increased the percentage of abnormal sperm within the epididymis. There was no significant effect on testis weight; however, the high-dose treatment significantly decreased the epididymis and seminal vesicle weights as well as overall body weight gain. Plasma luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone (T) levels were not affected by lead administration indicating that in adult male CF-1 mice, lead targets testicular spermatogenesis and sperm within the epididymis to produce reproductive toxicity rather than acting at other sites within the hypothalamic-pituitary-testicular axis.

UI	MeSH Term	Description	Entries
D007854	Lead	A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.
D008297	Male		Males
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D012098	Reproduction	The total process by which organisms produce offspring. (Stedman, 25th ed)	Human Reproductive Index,Human Reproductive Indexes,Reproductive Period,Human Reproductive Indices,Index, Human Reproductive,Indexes, Human Reproductive,Indices, Human Reproductive,Period, Reproductive,Periods, Reproductive,Reproductive Index, Human,Reproductive Indices, Human,Reproductive Periods
D001835	Body Weight	The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	Body Weights,Weight, Body,Weights, Body
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004326	Drinking	The consumption of liquids.	Water Consumption,Water Intake,Drinkings
D004822	Epididymis	The convoluted cordlike structure attached to the posterior of the TESTIS. Epididymis consists of the head (caput), the body (corpus), and the tail (cauda). A network of ducts leaving the testis joins into a common epididymal tubule proper which provides the transport, storage, and maturation of SPERMATOZOA.
D006728	Hormones	Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.	Hormone,Hormone Receptor Agonists,Agonists, Hormone Receptor,Receptor Agonists, Hormone
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations

Related Publications

S A Wadi, and G Ahmad

The effects of lead on the male rat reproductive system.

January 1989, Andrologia,

S A Wadi, and G Ahmad

Toxic effects of citrinin on the male reproductive system in mice.

July 2012, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie,

S A Wadi, and G Ahmad

Effects of butyl paraben on the male reproductive system in mice.

July 2002, Archives of toxicology,

S A Wadi, and G Ahmad

Effects of reserpine on the reproductive system of immature male mice.

January 1959, The Journal of experimental zoology,

S A Wadi, and G Ahmad

[Effects of nanosized cadmium sulfide on male reproductive system in mice].

December 2014, Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases,

S A Wadi, and G Ahmad

Male sterilization: effects on the male reproductive system.

January 1970, Medical gynaecology and sociology,

S A Wadi, and G Ahmad

Effects of stress on the reproductive system of male rats and mice.

May 1983, Archives of andrology,

S A Wadi, and G Ahmad

[Effects of nanosized titanium dioxide on the reproductive system of male mice].

June 2009, Zhonghua nan ke xue = National journal of andrology,

S A Wadi, and G Ahmad

Comparative effects of dimethoate and deltamethrin on reproductive system in male mice.

June 2010, Andrologia,