BIOMAT Database Logo BIOMAT Database Logo

Release of fibrinolytic activators from human ovarian tumours in organ culture. 1976

L Svanberg, and B Astedt

Malignant human ovarian tumours possess coagulative and fibrinolytic properties, reflected in the occurrence of fibrin/fibrinogen degradation products (FDP) in the serum or ascitic fluid. The degradation of fibrin/fibrinogen into FDP is initiated by activators of fibrinolysis. Using a culture method permitting continuous measurement of fibrinolytic activators released, we investigated this release in organ culture of 27 various human ovarian tumours and 7 normal ovaries. The results showed that ovarian tumour explants released more fibrinolytic enzymes than explants from normal ovaries.

UI MeSH Term Description Entries
D009924 Organ Culture Techniques A technique for maintenance or growth of animal organs in vitro. It refers to three-dimensional cultures of undisaggregated tissue retaining some or all of the histological features of the tissue in vivo. (Freshney, Culture of Animal Cells, 3d ed, p1) Organ Culture,Culture Technique, Organ,Culture Techniques, Organ,Organ Culture Technique,Organ Cultures
D010051 Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS. Cancer of Ovary,Ovarian Cancer,Cancer of the Ovary,Neoplasms, Ovarian,Ovary Cancer,Ovary Neoplasms,Cancer, Ovarian,Cancer, Ovary,Cancers, Ovarian,Cancers, Ovary,Neoplasm, Ovarian,Neoplasm, Ovary,Neoplasms, Ovary,Ovarian Cancers,Ovarian Neoplasm,Ovary Cancers,Ovary Neoplasm
D010053 Ovary The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE. Ovaries
D005260 Female Females
D005338 Fibrin Fibrinogen Degradation Products Soluble protein fragments formed by the proteolytic action of plasmin on fibrin or fibrinogen. FDP and their complexes profoundly impair the hemostatic process and are a major cause of hemorrhage in intravascular coagulation and fibrinolysis. Antithrombin VI,Fibrin Degradation Product,Fibrin Degradation Products,Fibrin Fibrinogen Split Products,Degradation Product, Fibrin,Degradation Products, Fibrin,Product, Fibrin Degradation
D005343 Fibrinolytic Agents Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN. Antithrombic Drug,Antithrombotic Agent,Antithrombotic Agents,Fibrinolytic Agent,Fibrinolytic Drug,Thrombolytic Agent,Thrombolytic Agents,Thrombolytic Drug,Antithrombic Drugs,Fibrinolytic Drugs,Thrombolytic Drugs,Agent, Antithrombotic,Agent, Fibrinolytic,Agent, Thrombolytic,Agents, Antithrombotic,Drug, Antithrombic,Drug, Fibrinolytic,Drug, Thrombolytic,Drugs, Antithrombic
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

L Svanberg, and B Astedt
On release and synthesis of fibrinolytic activators in human organ culture.
March 1972, Revue europeenne d'etudes cliniques et biologiques. European journal of clinical and biological research,
L Svanberg, and B Astedt
Release of fibrinolytic activators from human tumours cultured in vitro.
July 1972, Experientia,
L Svanberg, and B Astedt
Release of various molecular forms of plasminogen activators during culture of human ovarian tumours.
December 1978, Thrombosis research,
L Svanberg, and B Astedt
In vitro release of fibrinolytic activators from cornea.
May 1978, Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology,
L Svanberg, and B Astedt
Release of fibrinolytic activators from the cornea and conjunctiva.
January 1982, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
L Svanberg, and B Astedt
Following human tumours in primary organ culture.
January 1967, Neoplasma,
L Svanberg, and B Astedt
Androgen metabolism by human prostatic tumours in organ culture.
July 1983, European journal of cancer & clinical oncology,
L Svanberg, and B Astedt
Procoagulant and fibrinolytic activity of human ovarian carcinoma cells in culture.
April 1986, European journal of cancer & clinical oncology,
L Svanberg, and B Astedt
Release of fibrinolytic enzymes from human cornea.
January 1972, Acta ophthalmologica,
L Svanberg, and B Astedt
Organ culture of human endometrium. Effect of ovarian steroids.
November 1969, American journal of obstetrics and gynecology,
Copied contents to your clipboard!