Biomaterial Database

[Morphologic changes in the testes of white rats chronically subjected to vofatox 50]. 1976

M Zlateva, and E Maleva

The chronic action of the preparation vofatox 50 causes changes in the spermatopoeitic epithelium of white rats, which depend on the doses and duration of intoxication. There is an increased vascular permeability and degenerative changes in the spermatogenic epithelium, a reduction of the mitotic process and also index of spermatogenesis at the initial stages. The later changes are manifested by more formed changes in the spermatopoietic cells, appearance of gigantic multicellular forms, lack of sprematozoa in a large number of canaliclues and fibrosis of blood vessels. The changes in the testis are the result of the general toxic action of the preparation.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008743	Methyl Parathion	The methyl homolog of parathion. An effective, but highly toxic, organothiophosphate insecticide and cholinesterase inhibitor.	Metaphos,Parathion Methyl,Dalf,Metacid 50,Methylparathion,Vofatox,Wofatox
D010278	Parathion	A highly toxic cholinesterase inhibitor that is used as an acaricide and as an insecticide.	E-605,Ethyl Parathion,Phosphostigmine,Thiofos,Thiophos,Parathion, Ethyl
D002908	Chronic Disease	Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic
D003239	Connective Tissue Cells	A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.	Cell, Connective Tissue,Cells, Connective Tissue,Connective Tissue Cell
D004848	Epithelium	The layers of EPITHELIAL CELLS which cover the inner and outer surfaces of the cutaneous, mucus, and serous tissues and glands of the body.	Mesothelium,Epithelial Tissue,Mesothelial Tissue,Epithelial Tissues,Mesothelial Tissues,Tissue, Epithelial,Tissue, Mesothelial,Tissues, Epithelial,Tissues, Mesothelial
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013090	Spermatocytes	Male germ cells derived from SPERMATOGONIA. The euploid primary spermatocytes undergo MEIOSIS and give rise to the haploid secondary spermatocytes which in turn give rise to SPERMATIDS.	Spermiocytes,Spermatocyte,Spermiocyte
D013737	Testis	The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS.	Testicles,Testes,Testicle
D013997	Time Factors	Elements of limited time intervals, contributing to particular results or situations.	Time Series,Factor, Time,Time Factor