Biomaterial Database

Eliminating the need for dietary restrictions when using a sensitive guaiac fecal occult blood test. 1999

P Rozen, and J Knaani, and Z Samuel

Gastroenterology Department, Tel Aviv Medical Center, and Tel Aviv University, Israel.

When using the peroxidase-sensitive guaiac fecal occult blood test, Hemoccult Sensa (HOS), dietary restrictions are recommended so as to reduce its false positivity from ingested peroxidases. As dietary restrictions could reduce compliance for annual retesting, we reexamined their need. HOS was given to 944 persons in an endoscopic screening/follow-up program. Only the first 403 received instructions regarding a low peroxidase-containing diet for three days before and during HOS collection. Development was delayed 3-14 days after HOS preparation, and there were no significant differences in duration before HOS development in examinees with or without colorectal neoplasia and having or not having a positive test. Of the 901 persons without endoscopic evidence of neoplasia, 377 had received and 524 had not received instructions on dietary restrictions. Their HOS positivity was 7.2% and 5.5%, respectively (P = 0.26). When using HOS, delaying development by 3-14 days allows breakdown of ingested peroxidases, so dietary restrictions are not needed in our population, which has a low red meat intake.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008403	Mass Screening	Organized periodic procedures performed on large groups of people for the purpose of detecting disease.	Screening,Mass Screenings,Screening, Mass,Screenings,Screenings, Mass
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D009780	Occult Blood	Chemical, spectroscopic, or microscopic detection of extremely small amounts of blood.	Fecal Occult Blood Test,Blood, Occult
D010544	Peroxidases		Ovoperoxidase
D011795	Surveys and Questionnaires	Collections of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions.	Community Survey,Nonrespondent,Questionnaire,Questionnaires,Respondent,Survey,Survey Method,Survey Methods,Surveys,Baseline Survey,Community Surveys,Methodology, Survey,Nonrespondents,Questionnaire Design,Randomized Response Technique,Repeated Rounds of Survey,Respondents,Survey Methodology,Baseline Surveys,Design, Questionnaire,Designs, Questionnaire,Methods, Survey,Questionnaire Designs,Questionnaires and Surveys,Randomized Response Techniques,Response Technique, Randomized,Response Techniques, Randomized,Survey, Baseline,Survey, Community,Surveys, Baseline,Surveys, Community,Techniques, Randomized Response
D003113	Colonoscopy	Endoscopic examination, therapy or surgery of the luminal surface of the colon.	Colonoscopic Surgical Procedures,Surgical Procedures, Colonoscopic,Colonoscopic Surgery,Surgery, Colonoscopic,Colonoscopic Surgeries,Colonoscopic Surgical Procedure,Colonoscopies,Procedure, Colonoscopic Surgical,Procedures, Colonoscopic Surgical,Surgeries, Colonoscopic,Surgical Procedure, Colonoscopic
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man