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Elevated levels of anti-cardiolipin antibodies are associated with an increased risk for venous and arterial thrombosis. In patients with inflammatory bowel disease thrombosis is a well known complication. We determined the prevalence of elevated anti-cardiolipin antibodies in 136 patients with inflammatory bowel disease compared with 136 healthy controls and analyzed thromboembolic complications in patients with increased anti-cardiolipin antibody levels. Anti-cardiolipin antibody titers were significantly elevated in patients with Crohn's disease (5.7 units/ml) and ulcerative colitis (5.3 units/ml) compared to the control group (2.5 units/ml). We found no correlation between disease activity and anti-cardiolipin antibody levels. Seven patients had deep venous thrombosis in their history, in three of them this was complicated by pulmonary embolism. In only two of the seven patients with deep venous thrombosis were anti-cardiolipin antibody levels increased. In conclusion, anti-cardiolipin antibody titers were significantly increased in patients with inflammatory bowel disease. Elevated anti-cardiolipin antibody levels appear to play no role in the pathogenesis of thromboembolic events in patients with inflammatory bowel disease.
B W Aichbichler, and
W Petritsch, and
G A Reicht, and
H H Wenzl, and
A J Eherer, and
T A Hinterleitner, and
P Auer-Grumbach, and
G J Krejs
November 1998,
Digestive diseases and sciences,
B W Aichbichler, and
W Petritsch, and
G A Reicht, and
H H Wenzl, and
A J Eherer, and
T A Hinterleitner, and
P Auer-Grumbach, and
G J Krejs
June 2006,
Fukushima journal of medical science,
B W Aichbichler, and
W Petritsch, and
G A Reicht, and
H H Wenzl, and
A J Eherer, and
T A Hinterleitner, and
P Auer-Grumbach, and
G J Krejs
March 2008,
Clinical chemistry,
B W Aichbichler, and
W Petritsch, and
G A Reicht, and
H H Wenzl, and
A J Eherer, and
T A Hinterleitner, and
P Auer-Grumbach, and
G J Krejs
January 2003,
Hepato-gastroenterology,
B W Aichbichler, and
W Petritsch, and
G A Reicht, and
H H Wenzl, and
A J Eherer, and
T A Hinterleitner, and
P Auer-Grumbach, and
G J Krejs
December 2013,
Journal of Crohn's & colitis,
B W Aichbichler, and
W Petritsch, and
G A Reicht, and
H H Wenzl, and
A J Eherer, and
T A Hinterleitner, and
P Auer-Grumbach, and
G J Krejs
November 1995,
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B W Aichbichler, and
W Petritsch, and
G A Reicht, and
H H Wenzl, and
A J Eherer, and
T A Hinterleitner, and
P Auer-Grumbach, and
G J Krejs
January 2018,
PloS one,
B W Aichbichler, and
W Petritsch, and
G A Reicht, and
H H Wenzl, and
A J Eherer, and
T A Hinterleitner, and
P Auer-Grumbach, and
G J Krejs
January 1992,
Annales de medecine interne,
B W Aichbichler, and
W Petritsch, and
G A Reicht, and
H H Wenzl, and
A J Eherer, and
T A Hinterleitner, and
P Auer-Grumbach, and
G J Krejs
May 1987,
Revue du rhumatisme et des maladies osteo-articulaires,
B W Aichbichler, and
W Petritsch, and
G A Reicht, and
H H Wenzl, and
A J Eherer, and
T A Hinterleitner, and
P Auer-Grumbach, and
G J Krejs
December 2012,
Iranian journal of immunology : IJI,
